ReviewSeminars in immunopathology2022
Circadian regulation of innate immunity in animals and humans and implications for human disease.
Review in Seminars in immunopathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Effects of surgical timing on inflammatory responses, oxidative stress, and immune modulation in Wagyu calves following castration.BMC veterinary research · 2026Article
- Time of day of cardiac surgery and postoperative outcomes in the UK: a secondary analysis of linked national datasets.Anaesthesia · 2026Article
- Maternal circadian rhythm writes immune fate in offspring.Journal of biosciences · 2026Article
- The Circadian Modulators as Molecular Targets in Cancer-A Review.International journal of molecular sciences · 2025Review
- Influence of Extended Photoperiod Using Blue Light Masks on Hypertrichosis, Coat Condition and General Health Parameters in Horses with Pituitary Pars Intermedia Dysfunction.Animals : an open access journal from MDPI · 2025Article
- Circadian clocks and adaptive immune function: from mechanisms to therapeutic applications.Frontiers in immunology · 2025Review
- A randomized controlled trial examining the impact of diversified nursing interventions on the circadian rhythm of sedated critically ill patients.Frontiers in medicine · 2025Article
- The circadian regulator PER1 promotes cell reprogramming by inhibiting inflammatory signaling from macrophages.PLoS biology · 2023Article
- Circadian Gene Variants in Diseases.Genes · 2023Review
- Disruptions of Circadian Genes in Cutaneous Melanoma-An In Silico Analysis of Transcriptome Databases.International journal of molecular sciences · 2023Article
- The role of the circadian rhythms in critical illness with a focus on acute pancreatitis.Heliyon · 2023Review
- The human blood transcriptome exhibits time-of-day-dependent response to hypoxia: Lessons from the highest city in the world.Cell reports · 2022Article
- Chronoimmunology: from preclinical assessments to clinical applications.Seminars in immunopathology · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Circadian rhythms are 24-h oscillating variations in physiology generated by the core circadian clock. There is now a wide body of evidence showing circadian regulation of the immune system. Innate immune cells contain the molecular circadian clock which drives rhythmic responses, from the magnitude of the inflammatory response to the numbers of circulating immune cells varying throughout the day. This leads to rhythmic presentation of disease clinically, for example the classic presentation of nocturnal asthma or the sudden development of pulmonary oedema from acute myocardial infarction first thing in the morning.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.