Evidence map›Paper›PMID 35169708›Full record

ArticleBrain communications2022

Towards guided and automated programming of subthalamic area stimulation in Parkinson's disease.

San San Xu, Nicholas C Sinclair, Kristian J Bulluss, Thushara Perera, Wee-Lih Lee, Hugh J McDermott, Wesley Thevathasan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

San San XuBionics Institute, East Melbourne, VIC, Australia.
Nicholas C SinclairBionics Institute, East Melbourne, VIC, Australia.
Kristian J BullussBionics Institute, East Melbourne, VIC, Australia.
Thushara PereraBionics Institute, East Melbourne, VIC, Australia.
Wee-Lih LeeBionics Institute, East Melbourne, VIC, Australia.
Hugh J McDermottBionics Institute, East Melbourne, VIC, Australia.
Wesley ThevathasanBionics Institute, East Melbourne, VIC, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Selecting the ideal contact to apply subthalamic nucleus deep brain stimulation in Parkinson's disease can be an arduous process, with outcomes highly dependent on clinician expertise. This study aims to assess whether neuronal signals recorded intraoperatively in awake patients, and the anatomical location of contacts, can assist programming. In a cohort of 14 patients with Parkinson's disease, implanted with subthalamic nucleus deep brain stimulation, the four contacts on each lead in the 28 hemispheres were ranked according to proximity to a nominated ideal anatomical location and power of the following neuronal signals: evoked resonant neural activity, beta oscillations and high-frequency oscillations. We assessed how these rankings predicted, on each lead: (i) the motor benefit from deep brain stimulation applied through each contact and (ii) the 'ideal' contact to apply deep brain stimulation. The ranking of contacts according to each factor predicted motor benefit from subthalamic nucleus deep brain stimulation, as follows: evoked resonant neural activity;

Indexed as

deep brain stimulationevoked potentialslocal field potentialsParkinson’s diseasesubthalamic nucleus

Identifiers

PMID35169708
PMCPMC8833293

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.