Evidence map›Paper›PMID 35169703›Full record

ArticleBrain communications2022

The long and the short of Huntington's disease: how the sphingolipid profile is shifted in the caudate of advanced clinical cases.

Gabrielle R Phillips, Jennifer T Saville, Sarah E Hancock, Simon H J Brown, Andrew M Jenner, Catriona McLean, Maria Fuller, Kelly A Newell, Todd W Mitchell

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Gabrielle R PhillipsIllawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.ORCID https://orcid.org/0000-0001-9014-2771
Jennifer T SavilleGenetics and Molecular Pathology, SA Pathology at Women's and Children's Hospital, North Adelaide, SA 5006, Australia.
Sarah E HancockSchool of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
Simon H J BrownMolecular Horizons, University of Wollongong, Wollongong, NSW 2522, Australia.
Andrew M JennerBioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, University of New South Wales, Sydney, NSW 2052, Australia.
Catriona McLeanDepartment of Anatomical Pathology, Alfred Health and Florey Neuroscience, Parkville, VIC 3052, Australia.
Maria FullerGenetics and Molecular Pathology, SA Pathology at Women's and Children's Hospital, North Adelaide, SA 5006, Australia.
Kelly A NewellIllawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.
Todd W MitchellIllawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.
University of Wollongong · AUSouth Australia Pathology · AUAlfred Health · AUThe University of Sydney · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Huntington's disease is a devastating neurodegenerative disorder that onsets in late adulthood as progressive and terminal cognitive, psychiatric and motor deficits. The disease is genetic, triggered by a CAG repeat (polyQ) expansion mutation in the Huntingtin gene and resultant huntingtin protein. Although the mutant huntingtin protein is ubiquitously expressed, the striatum degenerates early and consistently in the disease. The polyQ mutation at the N-terminus of the huntingtin protein alters its natural interactions with neural phospholipids

Indexed as

glycosphingolipidHuntington's diseasemass spectrometrysphingolipidstriatum

Identifiers

PMID35169703
PMCPMC8833324
OpenAlexW4200487651

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.