Evidence map›Paper›PMID 35169687›Full record

ArticleiScience2022

Single-cell resolution of MET- and EMT-like programs in osteoblasts during zebrafish fin regeneration.

W Joyce Tang, Claire J Watson, Theresa Olmstead, Christopher H Allan, Ronald Y Kwon

Open access · goldAbstract read
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Loss ofJBMR plus · 2025
    Article
  4. Article
  5. Small Fish, Big Answers: Zebrafish and the Molecular Drivers of Metastasis.International journal of molecular sciences · 2025
    Review
  6. Epithelial-mesenchymal transition in tissue repair and degeneration.Nature reviews. Molecular cell biology · 2024
    Review
  7. Loss ofbioRxiv : the preprint server for biology · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

W Joyce TangDepartment of Orthopaedics and Sports Medicine, University of Washington School of Medicine, Seattle, WA 98105, USA.
Claire J WatsonDepartment of Orthopaedics and Sports Medicine, University of Washington School of Medicine, Seattle, WA 98105, USA.
Theresa OlmsteadDepartment of Orthopaedics and Sports Medicine, University of Washington School of Medicine, Seattle, WA 98105, USA.
Christopher H AllanDepartment of Orthopaedics and Sports Medicine, University of Washington School of Medicine, Seattle, WA 98105, USA.
Ronald Y KwonDepartment of Orthopaedics and Sports Medicine, University of Washington School of Medicine, Seattle, WA 98105, USA.
University of Washington · US

Funding

Identifying Osteoporosis Genes by Whole Genome Sequencing and Functional Validation in Zebra FishR01AR072199 · NIAMS · HEBREW REHABILITATION CENTER FOR AGED · PI HSU, YI-HSIANG · 2017 to 2022
$3.2M
Diversity Supplement for Rohda YaseR01AR074417 · NIAMS · UNIVERSITY OF WASHINGTON · PI KWON, RONALD Y · 2020 to 2025
$2.9M
Neuroskeletal Systems Biology in ZebrafishK01AR066061 · NIAMS · UNIVERSITY OF WASHINGTON · PI KWON, RONALD Y · 2015 to 2019
$614k
NIAMS NIH HHS K01 AR066061NIAMS NIH HHS R01 AR072199NIAMS NIH HHS R01 AR074417
6 · The paper itself

Abstract

Zebrafish regenerate fin rays following amputation through epimorphic regeneration, a process that has been proposed to involve the epithelial-to-mesenchymal transition (EMT). We performed single-cell RNA sequencing (scRNA-seq) to elucidate osteoblastic transcriptional programs during zebrafish caudal fin regeneration. We show that osteoprogenitors are enriched with components associated with EMT and its reverse, mesenchymal-to-epithelial transition (MET), and provide evidence that the EMT markers

Indexed as

Biological sciencesDevelopmental biologyOmicsTranscriptomics

Identifiers

PMID35169687
PMCPMC8829776
OpenAlexW4225542671

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.