ArticleEnvironmental epidemiology (Philadelphia, Pa.)2022
Early environmental quality and life-course mental health effects: The Equal-Life project.
Article in Environmental epidemiology (Philadelphia, Pa.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sleep as a potential link between exposome, mental health and cognitive development in children and adolescents - a scoping review.Archives of public health = Archives belges de sante publique · 2026Pooled it
- Assessing environmental exposures in children: toward a comprehensive exposome approach.Pediatric research · 2026Review
- Presymptomatic Screening for Risks to Children's Mental Health : Ethical Considerations from a European Focus Group Study with Mental Health Professionals.Journal of bioethical inquiry · 2026Article
- Machine learning framework for multidimensional assessment of urban quality of life.Scientific reports · 2026Article
- Exploring the exposome and unexplained variance in biological ageing - insights from a longitudinal twin study in adolescence and early adulthood.medRxiv : the preprint server for health sciences · 2026Article
- A new framework to consider equity in urban intervention planning, implementation and evaluation: development and application in a case study on an urban play spaces policy.BMC public health · 2026Article
- Cultural validation of the RCADS and use of ensemble learning for symptom profiling of anxiety and depression.Frontiers in psychiatry · 2026Article
- Association Between Extreme Heat and Externalizing Symptoms in Pre- and Early Adolescence: Findings From the ABCD Study.JAACAP open · 2025Article
- [Artificial intelligence in preventive medicine for children and adolescents-applications and acceptance].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2025Review
- The urban physical environment and leisure-time physical activity in early midlife: a FinnTwin12 study.Health & place · 2025Article
- Global research trends on the human exposome: a bibliometric analysis (2005-2024).Environmental science and pollution research international · 2025Review
- Lifestyle differences between co-twins are associated with decreased similarity in their internal and external exposome profiles.Scientific reports · 2024Article
- Age at separation, residential mobility, and depressive symptoms among twins in late adolescence and young adulthood: a FinnTwin12 cohort study.BMC public health · 2024Article
- The role of women in the field of early intervention.Heliyon · 2024Article
- Ethics of early detection of disease risk factors: A scoping review.BMC medical ethics · 2024Article
- Lifestyle differences between co-twins are associated with decreased similarity in their internal and external exposome profiles.medRxiv : the preprint server for health sciences · 2023Article
- Maternal and Child Health, Non-Communicable Diseases and Metabolites.Metabolites · 2023Review
- Perceived Occupational Noise Exposure and Depression in Young Finnish Adults.International journal of environmental research and public health · 2023Article
- Article
- Branched-chain amino acids linked to depression in young adults.Frontiers in neuroscience · 2022Article
Corrections and comments
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Authors and funding
28 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is increasing evidence that a complex interplay of factors within environments in which children grows up, contributes to children's suboptimal mental health and cognitive development. The concept of the life-course exposome helps to study the impact of the physical and social environment, including social inequities, on cognitive development and mental health over time.
methodsEqual-Life develops and tests combined exposures and their effects on children's mental health and cognitive development. Data from eight birth-cohorts and three school studies (N = 240.000) linked to exposure data, will provide insights and policy guidance into aspects of physical and social exposures hitherto untapped, at different scale levels and timeframes, while accounting for social inequities. Reasoning from the outcome point of view, relevant stakeholders participate in the formulation and validation of research questions, and in the formulation of environmental hazards. Exposure assessment combines GIS-based environmental indicators with omics approaches and new data sources, forming the early-life exposome. Statistical tools integrate data at different spatial and temporal granularity and combine exploratory machine learning models with hypothesis-driven causal modeling.
conclusionsEqual-Life contributes to the development and utilization of the exposome concept by (1) integrating the internal, physical and social exposomes, (2) studying a distinct set of life-course effects on a child's development and mental health (3) characterizing the child's environment at different developmental stages and in different activity spaces, (4) looking at supportive environments for child development, rather than merely pollutants, and (5) combining physical, social indicators with novel effect markers and using new data sources describing child activity patterns and environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.