Evidence map›Paper›PMID 35169646›Full record

ArticleHeliyon2022

The effects of sulfated secondary bile acids on intestinal barrier function and immune response in an inflammatory

Benthe van der Lugt, Maartje C P Vos, Mechteld Grootte Bromhaar, Noortje Ijssennagger, Frank Vrieling, Jocelijn Meijerink, Wilma T Steegenga

Open access · goldAbstract read
In one paragraph

Article in Heliyon, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. HumanTissue barriers · 2024
    Review
  8. Review
  9. Article
  10. Cytotoxic synergism ofWorld journal of gastroenterology · 2023
    Review
  11. Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Benthe van der LugtDivision of Human Nutrition and Health, Wageningen University & Research, Wageningen, the Netherlands.
Maartje C P VosDivision of Human Nutrition and Health, Wageningen University & Research, Wageningen, the Netherlands.
Mechteld Grootte BromhaarDivision of Human Nutrition and Health, Wageningen University & Research, Wageningen, the Netherlands.
Noortje IjssennaggerDepartment of Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, the Netherlands.
Frank VrielingDivision of Human Nutrition and Health, Wageningen University & Research, Wageningen, the Netherlands.
Jocelijn MeijerinkDivision of Human Nutrition and Health, Wageningen University & Research, Wageningen, the Netherlands.
Wilma T SteegengaDivision of Human Nutrition and Health, Wageningen University & Research, Wageningen, the Netherlands.
Wageningen University & Research · NLUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysbiosis-related perturbations in bile acid (BA) metabolism were observed in inflammatory bowel disease (IBD) patients, which was characterized by increased levels of sulfated BAs at the expense of secondary BAs. However, the exact effects of sulfated BAs on the etiology of IBD are not investigated yet. Therefore, we aimed to investigate the effects of sulfated deoxycholic acid (DCA), sulfated lithocholic acid (LCA) and their unsulfated forms on intestinal barrier function and immune response. To this end, we first established a novel

Indexed as

Inflammatory bowel diseaseIntestinal barrier functionMucus layerSecondary bile acidsSulfation

Identifiers

PMID35169646
PMCPMC8829581
OpenAlexW4225348263

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.