ArticleMedical archives (Sarajevo, Bosnia and Herzegovina)2021
Expression of Inflammatory Mediators in Periodontitis Over Established Diabetes: an Experimental Study in Rats.
Article in Medical archives (Sarajevo, Bosnia and Herzegovina), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 12 citations in OpenAlex.
- Expression of MMP-14 and CD147 in Gingival Tissue of Patients With and Without Diabetes Mellitus Type II.Diagnostics (Basel, Switzerland) · 2025Article
- Diagnoses Based on C-Reactive Protein Point-of-Care Tests.Biosensors · 2022Review
- Mediators of Periodontitis complementing the development of Neural Disorders.Pakistan journal of medical sciencesReview
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetes mellitus is characterized by hyperglycemia ensuing from deficiencies in insulin action, secretion, or both. Hyperglycemia has wide-ranging molecular and cellular effects, leading to oxidative stress, up-regulation of pro-inflammatory responses, and vascular changes.
objectivesThe aim of this study was to evaluate the expressions of inflammatory markers involved in periodontal destructive process occurring in diabetes, periodontitis (PD), and both coexisting conditions.
methodsA rat model was carried out using streptozotocin (STZ) to induce diabetes and Lipopolysaccharides (LPS) with teeth ligature to mimic periodontitis. The animals were distributed randomly into seven groups (n=12) and treated for 10 weeks with alternation between diabetes and PD. The relative quantification analysis of inflammatory markers expression: CRP, MMP-2-14, TIMP-2, IL-4, IFN-γ, was performed at the end of the experiments using western blot after protein isolation from periodontal tissue surrounding the ligation.
resultsThe data showed that CRP, MMP-2, MMP-14, TIMP-2, and IFN-γ are involved in the process of periodontal inflammation associated with diabetes. A significant increase (p<0.05) in the expression of inflammatory markers was detected when PD is associated with preexisting diabetes in comparison with diabetes superimposed on preexisting PD.
conclusionThis study demonstrated that already established diabetes worsens periodontitis more than diabetes upcoming on existing periodontitis.
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