Evidence map›Paper›PMID 35169232›Full record

ArticleMucosal immunology2022

A Notch/STAT3-driven Blimp-1/c-Maf-dependent molecular switch induces IL-10 expression in human CD4

Jonas Ahlers, Andrej Mantei, Laura Lozza, Manuela Stäber, Frederik Heinrich, Petra Bacher, Thordis Hohnstein, Lutz Menzel, Simge G Yüz, Daniel Alvarez-Simon and 8 more

Open access · hybridAbstract read
In one paragraph

Article in Mucosal immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
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  8. Article
  9. PD-1 expressing islet-specific CD4Immunology and cell biology · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. From bench to bedside: targeting lymphocyte activation gene 3 as a therapeutic strategy for autoimmune diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Review
  17. Type I regulatory T cells in malaria: of mice and men.The Journal of clinical investigation · 2023
    Article
  18. Association ofFrontiers in medicine · 2023
    Article
  19. Blimp-1 and c-Maf regulateWellcome open research · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 2 countries.

Jonas AhlersDepartment of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Andrej ManteiLabor Berlin, Charité Vivantes GmbH, Berlin, Germany.
Laura LozzaCell Biology, Precision for Medicine GmbH, Berlin, Germany.
Manuela StäberCentral Lab Service, Max-Plack-Institute for Infection Biology, Berlin, Germany.
Frederik HeinrichGerman Rheumatism Research Center (DRFZ) Berlin, Leibniz Association, Berlin, Germany.
Petra BacherInstitute of Immunology, Christian-Albrechts-University of Kiel & UKSH Schleswig-Holstein, Kiel, Schleswig-Holstein, Germany.
Thordis HohnsteinDepartment of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Lutz MenzelTranslational Tumor Immunology, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
Simge G YüzInstitute of Immunology, Christian-Albrechts-University of Kiel & UKSH Schleswig-Holstein, Kiel, Schleswig-Holstein, Germany.
Daniel Alvarez-SimonInstitute of Immunology, Christian-Albrechts-University of Kiel & UKSH Schleswig-Holstein, Kiel, Schleswig-Holstein, Germany.
Anne Rieke BickenbachInstitute of Immunology, Christian-Albrechts-University of Kiel & UKSH Schleswig-Holstein, Kiel, Schleswig-Holstein, Germany.
Carl WeidingerDepartment of Gastroenterology, Infectious Diseases and Rheumatology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Nadine Mockel-TenbrinckMiltenyi Biotec B.V. & Co.KG, Bergisch-Gladbach, Nordrhein-Westfalen, Germany.
Anja A KühliPATH, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Britta SiegmundDepartment of Gastroenterology, Infectious Diseases and Rheumatology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Jochen MaulDepartment of Gastroenterology, Infectious Diseases and Rheumatology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Christian Neumann *Department of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany. c.neumann@charite.de.
Alexander Scheffold *Institute of Immunology, Christian-Albrechts-University of Kiel & UKSH Schleswig-Holstein, Kiel, Schleswig-Holstein, Germany. Alexander.Scheffold@uksh.de.ORCID http://orcid.org/0000-0002-0626-343X
Charité - Universitätsmedizin Berlin · DEChristian-Albrechts-Universität zu Kiel · DEFranklin University · USLeibniz Association · DEMax Delbrück Center · DEMax Planck Institute for Infection Biology · DEMiltenyi Biotec (Germany) · DESanofi (Germany) · DEVivantes Klinikum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunosuppressive Interleukin (IL)-10 production by pro-inflammatory CD4

Indexed as

Crohn DiseaseInflammatory Bowel DiseasesAnimalsHumansInterleukin-10MiceMice, KnockoutProto-Oncogene Proteins c-mafSTAT3 Transcription FactorTh1 CellsInterleukin-10Maf protein, mouseProto-Oncogene Proteins c-mafSTAT3 protein, humanSTAT3 Transcription Factor

Identifiers

PMID35169232
PMCPMC9038525
OpenAlexW4212858326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.