Evidence map›Paper›PMID 35169201›Full record

ArticleScientific reports2022

Mice with a deficiency in Peroxisomal Membrane Protein 4 (PXMP4) display mild changes in hepatic lipid metabolism.

Maaike Blankestijn, Vincent W Bloks, Dicky Struik, Nicolette Huijkman, Niels Kloosterhuis, Justina C Wolters, Ronald J A Wanders, Frédéric M Vaz, Markus Islinger, Folkert Kuipers and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Parallel Selection for Longevity in Mammals and Birds.bioRxiv : the preprint server for biology · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. High Expression of PXMP4 in Hepatocellular Carcinoma Tissues.Asian Pacific journal of cancer prevention : APJCP · 2024
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Maaike BlankestijnDepartment of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Vincent W BloksDepartment of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Dicky StruikDepartment of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Nicolette HuijkmanDepartment of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Niels KloosterhuisDepartment of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Justina C WoltersDepartment of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Ronald J A WandersLaboratory of Genetic Metabolic Diseases, Department of Clinical Chemistry, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands.
Frédéric M VazLaboratory of Genetic Metabolic Diseases, Department of Clinical Chemistry, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands.
Markus IslingerInstitute of Neuroanatomy, Mannheim Center for Translational Neuroscience, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Folkert KuipersDepartment of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Bart van de SluisDepartment of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Albert K GroenDepartment of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Henkjan J VerkadeDepartment of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Johan W JonkerDepartment of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. j.w.jonker@umcg.nl.
University Medical Center Groningen · NLUniversity of Groningen · NLUniversity of Amsterdam · NLHeidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peroxisomes play an important role in the metabolism of a variety of biomolecules, including lipids and bile acids. Peroxisomal Membrane Protein 4 (PXMP4) is a ubiquitously expressed peroxisomal membrane protein that is transcriptionally regulated by peroxisome proliferator-activated receptor α (PPARα), but its function is still unknown. To investigate the physiological function of PXMP4, we generated a Pxmp4 knockout (Pxmp4

Indexed as

AnimalsBile Acids and SaltsCRISPR-Cas SystemsDietFatty AcidsFatty Acids, UnsaturatedFemaleFenofibrateGene EditingGene Knockout TechniquesLiverMaleMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutBile Acids and SaltsFatty AcidsFatty Acids, UnsaturatedFenofibrateMembrane ProteinsPhytanic AcidPhytolPPAR alphaPpara protein, mousepristanic acidPxmp4 protein, mouse

Identifiers

PMID35169201
PMCPMC8847483
OpenAlexW4213280393

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.