Evidence map›Paper›PMID 35169199›Full record

ArticleScientific reports2022

A gene signature consisting of ubiquitin ligases and deubiquitinating enzymes of SKP2 is associated with clinical outcome in breast cancer.

Lon W R Fong, Jangsoon Lee, Hui-Kuan Lin, Naoto T Ueno, Shuxing Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Lon W R FongIntelligent Molecular Discovery Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.
Jangsoon LeeDepartment of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Hui-Kuan LinDepartment of Cancer Biology, Wake Forest University Baptist Medical Center, Winston-Salem, NC, 27101, USA.
Naoto T UenoDepartment of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Shuxing ZhangIntelligent Molecular Discovery Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA. shuzhang@mdanderson.org.
The University of Texas MD Anderson Cancer Center · USAtrium Health Wake Forest Baptist · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ubiquitination of SKP2, an oncoprotein, is controlled by its E3 ligases, including APC/C

Indexed as

Breast NeoplasmsDeubiquitinating EnzymesFemaleHumansLymphatic MetastasisPrognosisS-Phase Kinase-Associated ProteinsSurvival RateUbiquitinationUbiquitin-Protein LigasesUbiquitin ThiolesteraseDeubiquitinating EnzymesSKP2 protein, humanS-Phase Kinase-Associated ProteinsUbiquitin-Protein LigasesUbiquitin ThiolesteraseUSP10 protein, human

Identifiers

PMID35169199
PMCPMC8847659
OpenAlexW4213336101

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.