ArticleScientific reports2022
Effect of substrate stiffness on friction in collective cell migration.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Guiding of Cell Migration over Sloped Steps Using TiOJournal of functional biomaterials · 2026Article
- Multi-phase field model reveals internal dissipation is crucial for spontaneous hole formation in cell monolayers.Nature communications · 2026Article
- HB-EGF enhances collective cell migration via spatial coordination of traction.APL bioengineering · 2026Article
- Emergent stable tissue shapes from the regulatory feedback between morphogens and cell growth.Journal of theoretical biology · 2026Article
- The Interplay Between Stiffness and Hyperglycemia on Diabetic Foot Ulcer Wound Closure.Cellular and molecular bioengineering · 2026Article
- Measurement of tissue viscosity to relate force and motion in collective cell migration.Soft matter · 2026Article
- Accessible and cost-effective methods for patterning cell monolayers on compliant substrates.PloS one · 2026Article
- Traction and Stress Control Formation and Motion of +1/2 Topological Defects in Epithelial Cell Monolayers.Newton ((New York, N.Y.) · 2025Article
- FAK Differentially Mechanoregulates Cell Migration during Wound Closure.ACS biomaterials science & engineering · 2025Article
- Emergent Stable Tissue Shapes from the Regulatory Feedback between Morphogens and Cell Growth.bioRxiv : the preprint server for biology · 2025Article
- Dual-purpose dynamics emerge from a heterogeneous cell population in Drosophila metamorphosis.PLoS computational biology · 2025Article
- A mathematical model suggests collectivity and inconstancy enhance the efficiency of neuronal migration in the adult brain.PLoS computational biology · 2025Article
- Emergence of multiple collective motility modes in a physical model of cell chains.NPJ systems biology and applications · 2025Article
- Substrate stress relaxation regulates monolayer fluidity and leader cell formation for collectively migrating epithelia.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Evaluating segmentation methods for UAV-Based Spoil Pile Delineation.Scientific reports · 2025Article
- Vertex model with internal dissipation enables sustained flows.Nature communications · 2025Article
- Interplay of actin nematodynamics and anisotropic tension controls endothelial mechanics.Nature physics · 2025Article
- Friction in soft biological systems and surface self-organization: the role of viscoelasticity.Biophysical reviews · 2024Review
- Intercellular friction and motility drive orientational order in cell monolayers.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Synergistic Biofilter Tube for Promoting Scarless Tendon Regeneration.Nano letters · 2024Article
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Authors and funding
3 authors.
Funding
Abstract
In collective cell migration, the motion results from forces produced by each cell and transmitted to the neighboring cells and to the substrate. Because inertia is negligible and the migration occurs over long time scales, the cell layer exhibits viscous behavior, where force and motion are connected by an apparent friction that results from the breaking and forming of adhesive bonds at the cell-cell and cell-substrate interfaces. Most theoretical models for collective migration include an apparent friction to connect force and motion, with many models making predictions that depend on the ratio of cell-cell and cell-substrate friction. However, little is known about factors that affect friction, leaving predictions of many theoretical models untested. Here, we considered how substrate stiffness and the number of adhesions affected friction at the cell-substrate interface. The experimental data were interpreted through prior theoretical models, which led to the same conclusion, that increased substrate stiffness increased the number of cell-substrate adhesions and caused increased cell-substrate friction. In turn, the friction affected the collective migration by altering the curvature at the edge of the cell layer. By revealing underlying factors affecting friction and demonstrating how friction perturbs the collective migration, this work provides experimental evidence supporting prior theoretical models and motivates the study of other ways to alter the collective migration by changing friction.
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