ArticleScientific reports2022
Differences in the serum metabolome profile of dairy cows according to the BHB concentration revealed by proton nuclear magnetic resonance spectroscopy (
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 33 citations in OpenAlex.
- Metabolic and Physiological Predictors of Enteric Methane Emissions in Early Lactation Dairy Cows: A Prospective Observational Study.Life (Basel, Switzerland) · 2025Article
- Integrating omics and functional data via representation learning to prioritize candidate genes for pleiotropic effect in dairy sheep.PNAS nexus · 2025Article
- Cumulative incidence of ketosis in fresh lactating cows: a case study in the United Arab Emirates.BMC veterinary research · 2025Article
- Ultrasound Back-Fat Thickness Association with Risk of Metabolic Disease of Dairy Cows in Early Lactation.Animals : an open access journal from MDPI · 2025Article
- Alanine Derived fromResearch (Washington, D.C.) · 2025Article
- Unravelling the Signature Follicular Fluid Metabolites in Dairy Cattle Follicles Growing Under Negative Energy Balance: An In Vitro Approach.International journal of molecular sciences · 2024Article
- Propylene Glycol Alleviates Oxidative Stress and Enhances Immunity in Ketotic Cows through Modulating Amino Acid and Lipid Metabolism.Antioxidants (Basel, Switzerland) · 2024Article
- Near-infrared spectroscopy analysis of blood plasma for predicting nonesterified fatty acid concentrations in dairy cows.JDS communications · 2024Article
- Biochemical profile differences during the transition period based on different levels of non-esterified fatty acids at 7 weeks before parturition in Mediterranean Italian dairy buffaloes (Frontiers in veterinary science · 2024Article
- Serum Metabolic Characterization of Vitamin E Deficiency inAnimals : an open access journal from MDPI · 2023Article
- Effect of Rumen-Protected Methionine on Metabolic Profile of Liver, Muscle and Blood Serum Samples of Growing German Simmental Bulls Fed Protein-Reduced Diets.Metabolites · 2023Article
- Impact of dry-off and lyophilized Aloe arborescens supplementation on plasma metabolome of dairy cows.Scientific reports · 2023Article
- Filling gaps in animal welfare assessment through metabolomics.Frontiers in veterinary science · 2023Review
- Metabolic signature ofFrontiers in veterinary science · 2023Article
- Dietary and Animal Strategies to Reduce the Environmental Impact of Pastoral Dairy Systems Result in Altered Nutraceutical Profiles in Milk.Animals : an open access journal from MDPI · 2022Article
- Changes in plasma fatty acids profile in hyperketonemic ewes during early lactation: a preliminary study.Scientific reports · 2022Article
- Evaluation of the metabolomic profile throughScientific reports · 2022Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mobilization of body reserves during the transition from pregnancy to lactation might predispose dairy cows to develop metabolic disorders such as subclinical ketosis or hyperketonemia. These conditions are not easily identifiable and are frequently related to other diseases that cause economic loss. The aim of this study was to evaluate the serum metabolome differences according to the β-hydroxybutyrate (BHB) concentration. Forty-nine Holstein Friesian dairy cows were enrolled between 15 and 30 days in milk. According to their serum BHB concentration, the animals were divided into three groups: Group 0 (G0; 12 healthy animals; BHB ≤ 0.50 mmol/L); Group 1 (G1; 19 healthy animals; 0.51 ≤ BHB < 1.0 mmol/L); and Group 2 (G2; 18 hyperketonemic animals; BHB ≥ 1.0 mmol/L). Animal data and biochemical parameters were examined with one-way ANOVA, and metabolite significant differences were examined by t-tests. Fifty-seven metabolites were identified in the serum samples. Thirteen metabolites showed significant effects and seemed to be related to the mobilization of body reserves, lipids, amino acid and carbohydrate metabolism, and ruminal fermentation.
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