ArticleScientific reports2022
Biomechanical duality of fracture healing captured using virtual mechanical testing and validated in ovine bones.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Dynamic Fracture Fixation Plates: A Systematic Review of Evolving Design Approaches.Annals of biomedical engineering · 2025Pooled it
- Patient-Specific Adaptation of a Mechano-Regulatory Bone-Healing Model Using Longitudinal Loading Data.Annals of biomedical engineering · 2026Article
- Automated and manual model creation workflows are equally reliable for virtual mechanical testing of ovine bone and fracture healing.Scientific reports · 2025Article
- Risk of fragility fracture is aggravated during bone regeneration processes in osteoporotic sheep.PloS one · 2025Article
- Experimental long bone fracture healing in goats with cockle shell-based calcium carbonate bone paste.Veterinary and animal science · 2024Article
- A Gellan Gum, Polyethylene Glycol, Hydroxyapatite Composite Scaffold with the Addition of Ginseng Derived Compound K with Possible Applications in Bone Regeneration.Gels (Basel, Switzerland) · 2024Article
- Adaptive Image Segmentation Reveals Substantial Cortical Bone Remodeling During Early Fracture Repair.Computer methods in biomechanics and biomedical engineering. Imaging & visualization · 2024Article
- rhBMP-2-loaded hydroxyapatite/beta-tricalcium phosphate microsphere/hydrogel composite promotes bone regeneration in a novel rat femoral nonunion model.Frontiers in bioengineering and biotechnology · 2024Article
- Combined electric and magnetic field therapy for bone repair and regeneration: an investigation in a 3-mm and an augmented 17-mm tibia osteotomy model in sheep.Journal of orthopaedic surgery and research · 2023Article
- Finite Element Analysis of Von Mises Stress in External Fixators for Open Tibial Fractures: A Comparative Study of ASTM F1541-02 and Tibia-Based Models in Indonesian Patients.Healthcare technology lettersArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone fractures commonly repair by forming a bridging structure called callus, which begins as soft tissue and gradually ossifies to restore rigidity to the bone. Virtual mechanical testing is a promising technique for image-based assessment of structural bone healing in both preclinical and clinical settings, but its accuracy depends on the validity of the material model used to assign tissue mechanical properties. The goal of this study was to develop a constitutive model for callus that captures the heterogeneity and biomechanical duality of the callus, which contains both soft tissue and woven bone. To achieve this, a large-scale optimization analysis was performed on 2363 variations of 3D finite element models derived from computed tomography (CT) scans of 33 osteotomized sheep under normal and delayed healing conditions. A piecewise material model was identified that produced high absolute agreement between virtual and physical tests by differentiating between soft and hard callus based on radiodensity. The results showed that the structural integrity of a healing long bone is conferred by an internal architecture of mineralized hard callus that is supported by interstitial soft tissue. These findings suggest that with appropriate material modeling, virtual mechanical testing is a reliable surrogate for physical biomechanical testing.
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