ReviewNPJ microgravity2022
A perspective on spaceflight associated neuro-ocular syndrome causation secondary to elevated venous sinus pressure.
Review in NPJ microgravity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Physiological adaptation of the jugular venous pulse during long-duration spaceflight.Scientific reports · 2026Article
- Ophthalmic and Visual System Changes in Human Spaceflight: A Review of Mechanisms, Measurement, and Countermeasures.Journal of clinical medicine · 2026Review
- Microgravity and cancer cells: from molecular mechanisms to therapeutic strategies.Cell death discovery · 2026Review
- Non invasive monitoring for spaceflight associated neuro ocular syndrome: responding to a need for In flight methodologies.NPJ microgravity · 2025Article
- Spaceflight-Associated Neuro-Ocular Syndrome and Idiopathic Intracranial Hypertension: Can Anemia and Hyperemia Underlie Both?AJNR. American journal of neuroradiology · 2024Article
- Reply.AJNR. American journal of neuroradiology · 2024Article
- A perspective on the evidence for glymphatic obstruction in spaceflight associated neuro-ocular syndrome and fatigue.NPJ microgravity · 2024Review
- Linking cerebral hemodynamics and ocular microgravity-induced alterations through an in silico-in vivo head-down tilt framework.NPJ microgravity · 2024Article
- Rheoencephalography: A non-invasive method for neuromonitoring.Journal of electrical bioimpedance · 2024Article
- Longitudinal Changes in Cerebral Perfusion, Perivascular Space Volume, and Ventricular Volume in a Healthy Cohort Undergoing a Spaceflight Analog.AJNR. American journal of neuroradiology · 2023Article
- The Fight against Cancer by Microgravity: The Multicellular Spheroid as a Metastasis Model.International journal of molecular sciences · 2022Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spaceflight associated neuro-ocular syndrome (SANS) alters the vision of astronauts during long-duration spaceflights. There is controversy regarding SANS being similar to patients with idiopathic intracranial hypertension (IIH). IIH has been shown to be due to an elevation in venous sinus pressure. The literature suggests an increase in jugular vein pressure secondary to a headward shift of fluid occurs in SANS but this may not be enough to significantly alter the intracranial pressure (ICP). The literature regarding cardiac output and cerebral blood flow (CBF) in long-duration spaceflight is contradictory, however, more recent data suggests increased flow. Recent modelling has shown that an increase in CBF can significantly increase sinus pressure. The purpose of the present paper is to review the SANS vascular dynamics literature and through mathematical modelling suggest the possible underlying cause of SANS as an elevation in venous sinus pressure, secondary to the redistribution of fluids towards the head, together with a significant increase in pressure drop across the venous system related to the CBF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.