ArticleScientific reports2022
Real-time large-area imaging of the corneal subbasal nerve plexus.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Design, implementation and evaluation of non-contact in vivo confocal microscopy for capturing the human corneal endothelium from the central to near-limbal regions.Zeitschrift fur medizinische Physik · 2026Article
- In vivo corneal microscopy: from image to insight - where are we going?Zeitschrift fur medizinische Physik · 2026Review
- Large-area 3D reconstruction of corneal tissues from oscillating focus confocal microscopy.Scientific reports · 2026Article
- Robust registration under large image misalignment using an iterative step-aware transformer with application to corneal confocal microscopy.Biomedical optics express · 2026Article
- ConNeCT: weakly supervised corneal confocal microscopy image inpainting network based on a diffusion model.Biomedical optics express · 2025Article
- Deep Corneal Nerve Plexus Selective Damage in Persistent Neurotrophic Corneal Epithelial Defects Detected by In Vivo Multiphoton Confocal Microscopy.Investigative ophthalmology & visual science · 2025Article
- Early Detection of Subclinical Corneal Abnormalities: Biophotonic Imaging Reveals Hyporeflective Bleb-Like Structures in Asymptomatic Eyes.The American journal of case reports · 2024Article
- Confocal Microscopy of the Cornea in Aqueous-Deficient Dry Eye Disease-A Literature Review.Diagnostics (Basel, Switzerland) · 2024Review
- Impact of implementation of polymerase chain reaction on diagnosis, treatment, and clinical course of Acanthamoeba keratitis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
- In-vivo corneal confocal microscopy: Imaging analysis, biological insights and future directions.Communications biology · 2023Review
- Taxane-Induced Neuropathy and Its Ocular Effects-A Longitudinal Follow-up Study in Breast Cancer Patients.Cancers · 2023Article
- Assessment of dynamic corneal nerve changes using static landmarks byQuantitative imaging in medicine and surgery · 2022Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The morphometric assessment of the corneal subbasal nerve plexus (SNP) by confocal microscopy holds great potential as a sensitive biomarker for various ocular and systemic conditions and diseases. Automated wide-field montages (or large-area mosaic images) of the SNP provide an opportunity to overcome the limited field of view of the available imaging systems without the need for manual, subjective image selection for morphometric characterization. However, current wide-field montaging solutions usually calculate the mosaic image after the examination session, without a reliable means for the clinician to predict or estimate the resulting mosaic image quality during the examination. This contribution describes a novel approach for a real-time creation and visualization of a mosaic image of the SNP that facilitates an informed evaluation of the quality of the acquired image data immediately at the time of recording. In cases of insufficient data quality, the examination can be aborted and repeated immediately, while the patient is still at the microscope. Online mosaicking also offers the chance to identify an overlap of the imaged tissue region with previous SNP mosaic images, which can be particularly advantageous for follow-up examinations.
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Registered trials
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