Evidence map›Paper›PMID 35169080›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Epistatic genetic interactions govern morphogenesis during sexual reproduction and infection in a global human fungal pathogen.

Sheng Sun, Cullen Roth, Anna Floyd Averette, Paul M Magwene, Joseph Heitman

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Dissecting the homeodomainbioRxiv : the preprint server for biology · 2025
    Article
  5. Unisexual reproduction in the global human fungal pathogenProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Unisexual reproduction in the global human fungal pathogenbioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Discovery of CONature microbiology · 2024
    Article
  9. Article
  10. Article
  11. Lessons learned: from mentored to mentor.The Journal of clinical investigation · 2023
    Article
  12. Article
  13. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Sheng SunDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.ORCID 0000-0002-2895-1153
Cullen RothDepartment of Biology, Duke University, Durham, NC 27708.
Anna Floyd AveretteDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.ORCID 0000-0002-5877-0812
Paul M MagweneDepartment of Biology, Duke University, Durham, NC 27708.ORCID 0000-0002-7659-2589
Joseph HeitmanDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710; heitm001@duke.edu.ORCID 0000-0001-6369-5995
Duke University · USDuke Medical Center · USDuke University Hospital · US

Funding

Structure, function, and evolution of the Cryptococcus MAT locusR01AI050113 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2002 to 2024
$8.5M
ROLE OF CALCINEURIN IN C. NEOFORMANS MATING AND FRUITINGR01AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 1997 to 2025
$6.7M
Genetics of Cryptococcus sexual reproductionR37AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2011 to 2020
$4.9M
The Genetic Basis of Virulence in Cryptococcus NeoformansR01AI133654 · NIAID · DUKE UNIVERSITY · PI JOSEPH HEITMAN, Paul Mitaari Magwene · 2017 to 2026
$4.7M
NIAID NIH HHS R01 AI039115NIAID NIH HHS R01 AI050113NIAID NIH HHS R01 AI133654NIAID NIH HHS R37 AI039115
6 · The paper itself

Abstract

Cellular development is orchestrated by evolutionarily conserved signaling pathways, which are often pleiotropic and involve intra- and interpathway epistatic interactions that form intricate, complex regulatory networks.

Indexed as

Biological EvolutionCryptococcosisCryptococcusEpistasis, GeneticFungal ProteinsGenes, Mating Type, FungalHyphaeMorphogenesisPhenotypeQuantitative Trait LociReproductionReproduction, AsexualFungal Proteinscell developmentCryptococcusgenetic variationpathogenicityQTL

Identifiers

PMID35169080
PMCPMC8872808
OpenAlexW4220850983

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.