ArticleThe European respiratory journal2022
Effects of COVID-19 protective face masks and wearing durations on respiratory haemodynamic physiology and exhaled breath constituents.
Article in The European respiratory journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Physio-metabolic and clinical consequences of wearing face masks-Systematic review with meta-analysis and comprehensive evaluation.Frontiers in public health · 2023Pooled it
- Surgical masks and filtering facepiece class 2 respirators (FFP2) have no major physiological effects at rest and during moderate exercise at 3000-m altitude: a randomised controlled trial.Journal of travel medicine · 2023Trial
- Effects of wearing different face masks on cardiopulmonary performance at rest and exercise in a partially double-blinded randomized cross-over study.Scientific reports · 2023Trial
- Risks and benefits of face masks in children.Frontiers in pediatrics · 2026Review
- Balancing strategies in vaccination and mask-wearing for Chinese medical staff in post-COVID-19 era: a modelling study and cost-effectiveness analysis.Journal of global health · 2025Article
- Estimating hypoxia-induced brain dysfunction and cognitive decline through exhaled breath monitoring.Respiratory research · 2025Article
- Assessing the impact of different types of masks on COPD patients: a randomised controlled trial.ERJ open research · 2025Article
- Exhaled breath metabolites reveal postmenopausal gut-bone cross-talk and non-invasive markers for osteoporosis.Communications medicine · 2024Article
- The influence of N95 and surgical masks on carbon dioxide levels: A comprehensive systematic review and meta-analysis.Heliyon · 2024Article
- Effects of Contagious Respiratory Pathogens on Breath Biomarkers.Antioxidants (Basel, Switzerland) · 2024Article
- Effective volume of rebreathed air during breathing with facepieces increases with protection class and decreases with ambient airflow.PloS one · 2024Article
- The bacterial burden of worn face masks-observational research and literature review.Frontiers in public health · 2024Review
- Origin of breath isoprene in humans is revealed via multi-omic investigations.Communications biology · 2023Article
- Capillary carbon dioxide tension increases in hospital staff wearing filtering facepiece masks: a prospective crossover study.ERJ open research · 2023Article
- Reply to Commentaries-"Is mask wearing hazardous for children? No the evidence is insufficient." by Kenzo Takahashi and Tetsuya Tanimoto & comments by Patrick Steinle and Michael F. Koller.Environmental research · 2023Article
- Article
- With or without the Mask: Age Differences in Perceived Trustworthiness and Health during the COVID-19 Pandemic.Behavioral sciences (Basel, Switzerland) · 2023Article
- A study of the relationship between social anxiety and mask-wearing intention among college students in the post-COVID-19 era: mediating effects of self-identity, impression management, and avoidance.Frontiers in psychology · 2023Article
- Evaluation of respiratory function in healthcare workers wearing face masks during the COVID-19 pandemic.The American journal of emergency medicine · 2023Article
- Advanced setup for safe breath sampling and patient monitoring under highly infectious conditions in the clinical environment.Scientific reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile assumed to protect against coronavirus transmission, face masks may have effects on respiratory-haemodynamic parameters. Within this pilot study, we investigated immediate and progressive effects of FFP2 and surgical masks on exhaled breath constituents and physiological attributes in 30 adults at rest.
methodsWe continuously monitored exhaled breath profiles within mask space in older (age 60-80 years) and young to middle-aged (age 20-59 years) adults over the period of 15 and 30 min by high-resolution real-time mass-spectrometry. Peripheral oxygen saturation (
resultsProfound, consistent and significant (p≤0.001) changes in
conclusionsBreathomics allows unique physiometabolic insights into immediate and transient effects of face mask wearing. Physiological parameters and breath profiles of endogenous and/or exogenous volatile metabolites indicated putative cross-talk between transient hypoxaemia, oxidative stress, hypercarbia, vasoconstriction, altered systemic microbial activity, energy homeostasis, compartmental storage and washout. FFP2 masks had a more pronounced effect than surgical masks. Older adults were more vulnerable to FFP2 mask-induced hypercarbia, arterial oxygen decline, blood pressure fluctuations and concomitant physiological and metabolic effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.