Evidence map›Paper›PMID 35169021›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

AMIGO1 Promotes Axon Growth and Territory Matching in the Retina.

Florentina Soto, Ning Shen, Daniel Kerschensteiner

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Florentina SotoJohn F. Hardesty, MD, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri 63110 sotof@wustl.edu dkerschensteiner@wustl.edu.
Ning ShenJohn F. Hardesty, MD, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri 63110.ORCID 0000-0003-0628-3497
Daniel KerschensteinerJohn F. Hardesty, MD, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri 63110 sotof@wustl.edu dkerschensteiner@wustl.edu.
Washington University in St. Louis · USWuyi University · CN

Funding

WASHINGTON UNIVERSITY CENTER VISION RESEARCHP30EY002687 · NEI · WASHINGTON UNIVERSITY · PI Philip Raymond Williams · 1985 to 2026
$18.4M
SYNAPTIC ORGANIZATION AND VISUAL PROCESSING IN INTERNEURON CIRCUITS OF THE RETINAR01EY026978 · NEI · WASHINGTON UNIVERSITY · PI Daniel Kerschensteiner · 2016 to 2026
$3.8M
Synapse rescue and neuroprotection in the retinaR01EY027411 · NEI · WASHINGTON UNIVERSITY · PI Daniel Kerschensteiner · 2017 to 2026
$3.4M
Neuronal plasticity in retinal circuit development and diseaseR01EY023341 · NEI · WASHINGTON UNIVERSITY · PI KERSCHENSTEINER, DANIEL · 2014 to 2022
$2.8M
Visual pathway cooperation to align viewing strategies and processing specializations for predationR01EY034001 · NEI · WASHINGTON UNIVERSITY · PI Daniel Kerschensteiner · 2022 to 2026
$2.0M
NEI NIH HHS P30 EY002687NEI NIH HHS R01 EY023341NEI NIH HHS R01 EY026978NEI NIH HHS R01 EY027411NEI NIH HHS R01 EY034001
6 · The paper itself

Abstract

Dendrite and axon arbor sizes are critical to neuronal function and vary widely between different neuron types. The relative dendrite and axon sizes of synaptic partners control signal convergence and divergence in neural circuits. The developmental mechanisms that determine cell-type-specific dendrite and axon size and match synaptic partners' arbor territories remain obscure. Here, we discover that retinal horizontal cells express the leucine-rich repeat domain cell adhesion molecule AMIGO1. Horizontal cells provide pathway-specific feedback to photoreceptors-horizontal cell axons to rods and horizontal cell dendrites to cones. AMIGO1 selectively expands the size of horizontal cell axons. When

Indexed as

DendritesRetinaAnimalsAxonsMiceRetinal Bipolar CellsRetinal Cone Photoreceptor Cellsarbor sizecircuit developmenthorizontal cellLRR proteinrod bipolar pathway

Identifiers

PMID35169021
PMCPMC8973419
OpenAlexW4212824390

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.