Evidence map›Paper›PMID 35168787›Full record

ArticleMethods in enzymology2022

In silico prediction and mass spectrometric characterization of botanical antimicrobial peptides.

Kevin D Culver, Leslie M Hicks

Open access · greenAbstract read
In one paragraph

Article in Methods in enzymology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kevin D CulverDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Leslie M HicksDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States. Electronic address: lmhicks@unc.edu.
University of North Carolina at Chapel Hill · US

Funding

PepSAVI-MS for discovery of novel botanical antimicrobial peptidesR01GM125814 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HICKS, LESLIE M. · 2018 to 2022
$1.6M
NIGMS NIH HHS R01 GM125814
6 · The paper itself

Abstract

Antimicrobial peptides (AMPs) are promising compounds for the treatment of antibiotic-resistant bacteria and are found across all organisms, including plants. Unlike most antibiotics, AMPs tend to act on more generalized and multiple targets, making development of resistance more difficult. Conventional approaches toward AMP identification include bioactivity-guided fractionation and genome mining. Complementary methods leveraging bioactivity-guided fractionation, cysteine motif-guided in silico AMP prediction, and mass spectrometric approaches can be combined to expand botanical AMP discovery. Herein, we present an integrated workflow which serves to streamline implementation toward a robust botanical AMP discovery pipeline.

Indexed as

Anti-Bacterial AgentsAntimicrobial PeptidesBacteriaMass SpectrometryAnti-Bacterial AgentsAntimicrobial PeptidesAntimicrobial peptidesCysmotif searcherMass shiftMass spectrometryPepSAVI-MSSignalP

Identifiers

PMID35168787
PMCPMC10935602
OpenAlexW4211111925

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.