Evidence map›Paper›PMID 35168714›Full record

ReviewInfectious disease clinics of North America2022

Tuberculosis in Children.

Devan Jaganath, Jeanette Beaudry, Nicole Salazar-Austin

Registry-linked trialAbstract readReview
In one paragraph

Review in Infectious disease clinics of North America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05989802 (Rapid Research in Diagnostics Development for Tuberculosis Network), which is not on this map. Cited by 39 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05989802 narecruitingnot on this mapstarted 2024, after this paper: background citation

Rapid Research in Diagnostics Development for Tuberculosis Network (R2D2 Kids) and Assessing Diagnostics At Point-of-care for Tuberculosis in Children (ADAPT for Kids)

TypeinterventionalSponsorUniversity of California, San FranciscoRan2024 to 2026Enrolled2,100ConditionsTuberculosis, Diagnostics, Global HealthArmsOral swab molecular testing, Automated Cough Sound Analysis, Automated Lung Sound Analysis, Chest X Ray Computer Aided Detection
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Devan JaganathDivision of Pediatric Infectious Diseases, University of California, San Francisco, 1001 Potrero Avenue, Building 3, Room 635A, Box 1234, San Francisco, CA 94110, USA.
Jeanette BeaudryDivision of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, 200 N. Wolfe Street, Room 3150, Baltimore, MD 21287, USA.
Nicole Salazar-AustinDivision of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, 200 N Wolfe Street, Room 3147, Baltimore, MD 21287, USA. Electronic address: nsalaza1@jhmi.edu.

Funding

Host Proteomic Biosignatures for a Urine-based Diagnosis of Pulmonary Tuberculosis in ChildrenK23HL153581 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JAGANATH, DEVAN · 2020 to 2024
$946k
Task-Shifting Pediatric TB/HIV Prevention to Community Health Workers in South AfricaK23HD096973 · NICHD · JOHNS HOPKINS UNIVERSITY · PI SALAZAR-AUSTIN, NICOLE · 2019 to 2022
$682k
NHLBI NIH HHS K23 HL153581NHLBI NIH HHS L40 HL143644NICHD NIH HHS K23 HD096973
6 · The paper itself

Abstract

Tuberculosis (TB) is one of the leading causes of mortality in children worldwide, but there remain significant challenges in diagnosing and treating TB infection and disease. Treatment of TB infection in children and adolescents is critical to prevent progression to TB disease and to prevent them from becoming the future reservoir for TB transmission. This article reviews the clinical approach to diagnosing and treating latent TB infection and pulmonary and extrapulmonary TB disease in children. Also discussed are emerging diagnostics and therapeutic regimens that aim to improve pediatric TB detection and outcomes.

Indexed as

TuberculosisAdolescentChildHumansChildDiagnosisPreventionTBTreatmentTuberculosis

Identifiers

PMID35168714
PMCPMC8867883

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.