ArticleJournal of orthopaedic surgery and research2022
Positive association between high-density lipoprotein cholesterol and bone mineral density in U.S. adults: the NHANES 2011-2018.
Article in Journal of orthopaedic surgery and research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 101 citations in OpenAlex.
- Article
- Sex differences in the association between bone mineral density and lipid profiles in people with type 2 diabetes in southwest China.Metabolism open · 2026Article
- Non-HDL to HDL cholesterol ratio as a potential biomarker for osteoporosis: A cross-sectional national population study.Medicine · 2026Article
- Association between systemic immune-inflammatory markers and monoclonal gammopathy of undetermined significance in the elderly population: findings from the National health and nutrition examination survey.Clinical and experimental medicine · 2026Article
- Novel association between atherogenic index of plasma and bone mineral density in men: a retrospective analysis.BMC endocrine disorders · 2026Article
- Article
- Association of high-density lipoprotein with P1NP and β-CTX in hospitalized patients with osteoporotic fractures: a retrospective cross-sectional study.Frontiers in endocrinology · 2026Article
- Association between the serum uric acid to HDL cholesterol ratio and forearm bone mineral density in middle-aged and older adults.Frontiers in endocrinology · 2026Article
- The Association between Remnant Cholesterol Levels and Computed Tomography-based Low Bone Mass, Low Muscle Mass, and Osteosarcopenia in Older AdultsCurrent medical imaging · 2026Article
- The triglyceride-to-HDL cholesterol ratio is associated with lower BMD in older adults at high altitudes: a retrospective retrospective cross sectional study.Frontiers in endocrinology · 2026Article
- Association between high-density-lipoprotein cholesterol and postoperative recovery from lumbar disc herniation.PloS one · 2026Article
- High-density lipoprotein-related inflammation indices and reproductive lifespan in women: insights from NHANES 2007-2018.BMC women's health · 2025Article
- Non-linear associations between UHR and bone mineral density in US adults: NHANES 2017-2018.European journal of medical research · 2025Article
- Association between high-density lipoprotein cholesterol-related inflammatory markers and female infertility: a cross-sectional analysis from the National Health and Nutrition Examination Survey (NHANES 2013-2018).BMC women's health · 2025Article
- Characterizing the Lipid Profile in Patients with Vertebral or Hip Fragility Fractures: A Hospital-Based Descriptive Study.Journal of clinical medicine · 2025Article
- L-shaped association of the non-high-density lipoprotein to high-density lipoprotein ratio with low bone mass disorders.Scientific reports · 2025Article
- Association between Non high density lipoprotein to high density lipoprotein cholesterol ratio and bone mineral density.Scientific reports · 2025Article
- Association between total dietary choline intake and lumbar spine bone mineral density in postmenopausal women based on NHANES 2007-2018.Scientific reports · 2025Article
- Heavy metals and their relationships with lung function and airway inflammation: insights from a population-based study.Journal of translational medicine · 2025Article
- Association of serum neurofilament light chain and bone mineral density in adults.BMC musculoskeletal disorders · 2025Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSerum lipids are highly inheritable and play a major role in bone health. However, the relationship between high-density lipoprotein cholesterol (HDL-C) and bone mineral density (BMD) remains uncertain. The goal of this study was to see if there was a link between HDL-C levels and BMD in persons aged 20-59.
methodsMultivariate logistic regression models were used to determine the link between HDL-C and lumbar BMD using data from the National Health and Nutrition Examination Survey (NHANES) 2011-2018. Generalized additive models and fitted smoothing curves were also used.
resultsThe analysis included a total of 10,635 adults. After controlling for various variables, we discovered that HDL-C was positively linked with lumbar BMD. The favorable connection of HDL-C with lumbar BMD was maintained in subgroup analyses stratified by sex and race in women, but not in men, and in blacks, but not in whites. The relationship between HDL-C and lumbar BMD in men and whites was a U-shaped curve with the same inflection point: 0.98 mmol/L.
conclusionsIn people aged 20 to 59, our research discovered a positive relationship among HDL-C and lumbar BMD. Among males and whites, this relationship followed a U-shaped curve (inflection point: 0.98 mmol/L). HDL-C measurement might be used as a responsive biomarker for detecting osteoporosis early and guiding therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.