Evidence map›Paper›PMID 35168627›Full record

ArticleArthritis research & therapy2022

CD34

Seiji Noda, Tadashi Hosoya, Yoji Komiya, Yasuhiro Tagawa, Kentaro Endo, Keiichiro Komori, Hideyuki Koga, Yasuhiro Takahara, Kazutaka Sugimoto, Ichiro Sekiya and 3 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis research & therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
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  5. Article
  6. Article
  7. Article
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  9. Article
  10. Review
  11. Article
  12. Article
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  14. [Analysis of the types and functions of CD34Zhonghua shao shang yu chuang mian xiu fu za zhi · 2024
    Article
  15. Article
  16. Review
  17. Correction: CD34Arthritis research & therapy · 2022
    Article
  18. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Seiji NodaDepartment of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Tadashi HosoyaDepartment of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Yoji KomiyaDepartment of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Yasuhiro TagawaDepartment of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Kentaro EndoCenter for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Keiichiro KomoriCenter for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Hideyuki KogaDepartment of Joint Surgery and Sports Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Yasuhiro TakaharaDepartment of Orthopedics, Nippon Koukan Fukuyama Hospital, Fukuyama, Japan.
Kazutaka SugimotoDepartment of Orthopedics, Sonodakai Joint Replacement Center Hospital, Tokyo, Japan.
Ichiro SekiyaCenter for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Tetsuya SaitoDepartment of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Fumitaka MizoguchiDepartment of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Shinsuke YasudaDepartment of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan. syasuda.rheu@tmd.ac.jp.ORCID http://orcid.org/0000-0001-6171-2077
Tokyo Medical and Dental University · JPFukuyama Cardiovascular Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveSynovial fibroblasts (SFs) in rheumatoid arthritis (RA) and osteoarthritis (OA) play biphasic roles in joint destruction and regeneration of bone/cartilage as mesenchymal stem cells (MSCs). Although MSCs contribute to joint homeostasis, such function is impaired in arthritic joints. We have identified functionally distinct three SF subsets characterized by the expression of CD34 and THY1 as follows: CD34

methodsSF subsets were isolated from synovial tissues of 70 patients (RA: 18, OA: 52). Expressions of surface markers associated with MSCs (THY1, CD34, CD73, CD271, CD54, CD44, and CD29) were evaluated in fleshly isolated SF subsets by flow cytometry. The differentiation potentials of osteogenesis, chondrogenesis, and adipogenesis were evaluated with histological staining and a quantitative polymerase chain reaction of differentiation marker genes. Small interfering RNA was examined to deplete THY1 in SFs.

resultsThe expression levels of THY1

conclusionThe CD34

Indexed as

ChondrogenesisMesenchymal Stem CellsCell DifferentiationCells, CulturedChondrocytesFibroblastsHumansOsteogenesisSynovial Membrane

Identifiers

PMID35168627
PMCPMC8845288
OpenAlexW4221069603

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.