Evidence map›Paper›PMID 35168405›Full record

ArticleCell transplantation

MGP Regulates Perivascular Adipose-Derived Stem Cells Differentiation Toward Smooth Muscle Cells Via BMP2/SMAD Pathway Enhancing Neointimal Formation.

Hui Ni, Chang Liu, Yuwen Chen, Yunrui Lu, Yongli Ji, Meixiang Xiang, Yao Xie

Open access · goldAbstract read
In one paragraph

Article in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hui NiDepartment of Cardiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.ORCID 0000-0003-4125-3795
Chang LiuDepartment of Cardiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Yuwen ChenDepartment of Cardiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Yunrui LuDepartment of Cardiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Yongli JiDepartment of Cardiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Meixiang XiangDepartment of Cardiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Yao XieDepartment of Cardiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Second Affiliated Hospital of Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Perivascular adipose-derived stem cells (PV-ADSCs) could differentiate into smooth muscle cells (SMCs), participating in vascular remodeling. However, its underlying mechanism is not well explored. Our previous single-cell RNA-sequencing dataset identified a unique expression of matrix Gla protein (MGP) in PV-ADSCs compared with subcutaneous ADSCs. MGP involves in regulating SMC behaviors in vascular calcification and atherosclerosis. In this study, we investigated MGP's role in PV-ADSCs differentiation toward SMCs

Indexed as

Bone Morphogenetic Protein 2Extracellular Matrix ProteinsAnimalsCalcium-Binding ProteinsCell DifferentiationCells, CulturedMatrix Gla ProteinMiceMyocytes, Smooth MuscleStem CellsBone Morphogenetic Protein 2Calcium-Binding ProteinsExtracellular Matrix ProteinsMatrix Gla ProteinBMP2/SMAD pathwaycell differentiationMGPPV-ADSCsSMCs

Identifiers

PMID35168405
PMCPMC8855449
OpenAlexW4213022031

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.