Evidence map›Paper›PMID 35168367›Full record

ArticleBone & joint research2022

Total and partial knee arthroplasty implants that maintain native load transfer in the tibia.

Maxwell J Munford, Jennifer C Stoddart, Alexander D Liddle, Justin P Cobb, Jonathan R T Jeffers

Open access · goldAbstract read
In one paragraph

Article in Bone & joint research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Maxwell J MunfordThe Biomechanics Group, Department of Mechanical Engineering, Imperial College London, London, UK.ORCID 0000-0002-8400-0299
Jennifer C StoddartThe Biomechanics Group, Department of Mechanical Engineering, Imperial College London, London, UK.
Alexander D LiddleThe MSk Lab, Department of Surgery and Cancer, Imperial College London, London, UK.
Justin P CobbThe MSk Lab, Department of Surgery and Cancer, Imperial College London, London, UK.
Jonathan R T JeffersThe Biomechanics Group, Department of Mechanical Engineering, Imperial College London, London, UK.
Imperial College London · GB

Funding

Wellcome Trust 208858/Z/17/Z
6 · The paper itself

Abstract

aimsUnicompartmental and total knee arthroplasty (UKA and TKA) are successful treatments for osteoarthritis, but the solid metal implants disrupt the natural distribution of stress and strain which can lead to bone loss over time. This generates problems if the implant needs to be revised. This study investigates whether titanium lattice UKA and TKA implants can maintain natural load transfer in the proximal tibia.

methodsIn a cadaveric model, UKA and TKA procedures were performed on eight fresh-frozen knee specimens, using conventional (solid) and titanium lattice tibial implants. Stress at the bone-implant interfaces were measured and compared to the native knee.

resultsTitanium lattice implants were able to restore the mechanical environment of the native tibia for both UKA and TKA designs. Maximum stress at the bone-implant interface ranged from 1.2 MPa to 3.3 MPa compared with 1.3 MPa to 2.7 MPa for the native tibia. The conventional solid UKA and TKA implants reduced the maximum stress in the bone by a factor of 10 and caused > 70% of bone surface area to be underloaded compared to the native tibia.

conclusionTitanium lattice implants maintained the natural mechanical loading in the proximal tibia after UKA and TKA, but conventional solid implants did not. This is an exciting first step towards implants that maintain bone health, but such implants also have to meet fatigue and micromotion criteria to be clinically viable. Cite this article:

Indexed as

Additive manufacturingbone-implantBone straincadaveric studykneeknee arthroplasty implantsPorous implantsproximal tibiatibial bonetibial implantstitaniumtotal knee arthroplasty (TKA)unicompartmental knee arthroplasty (UKA)

Identifiers

PMID35168367
PMCPMC8882327
OpenAlexW4212842480

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.