ArticleNature2022
Germinal centre-driven maturation of B cell response to mRNA vaccination.
Open access · bronzeAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 237 papers.
0numbers the graph read from it
0cells of the map it votes in
237citing papers in PubMed
28.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
237 citing papers in PubMed, 351 citations in OpenAlex.
- HIV-1 envelope trimer vaccine induces sex-associated differences in antibody responses: a phase 1 clinical trial.Nature communications · 2025Trial
- Anti-neuraminidase and anti-hemagglutinin stalk responses to different influenza a(H7N9) vaccine regimens.Vaccine · 2025Trial
- A Phase 2 Clinical Trial to Evaluate the Safety, Reactogenicity, and Immunogenicity of Different Prime-Boost Vaccination Schedules of 2013 and 2017 A(H7N9) Inactivated Influenza Virus Vaccines Administered With and Without AS03 Adjuvant in Healthy US Adults.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Trial
- An mRNA-lipid nanoparticle vaccine targeting theMolecular therapy. Nucleic acids · 2026Article
- Peripheral B-cell receptor immunoglobulin heavy chain repertoire as a potential biomarker for frequently relapsing nephrotic syndrome in children.Renal failure · 2026Article
- Mechanisms and determinants of mRNALipid Nanoparticle biodistribution: From pharmacokinetics to clinical translation.Bioengineering & translational medicine · 2026Review
- COVID-19 mRNA Vaccines as Antigen-Agnostic Immunomodulators: A Repurposing Perspective.Medical sciences (Basel, Switzerland) · 2026Review
- mRNA-1010 and the Future of Seasonal Influenza Prevention: Towards Next-Generation Respiratory Vaccination.Vaccines · 2026Article
- Rapid discovery of monoclonal antibodies via high-throughput single BCR affinity sequencing.Nucleic acids research · 2026Article
- Vitamin B5 supports anti-PD1 response in HER2-positive gastric cancer and enhances interaction between naïve B cells and T cells.Nature communications · 2026Article
- Transfer RNA Modifications in the Immune System Participate in Disease Pathogenesis.International journal of molecular sciences · 2026Review
- mRNA-based influenza vaccine expands the B cell response breadth in humans.Nature immunology · 2026Observational
- Human primary antibody response to vaccination follows a partially sequential class-switching program with a checkpoint at IGHG2.Cell reports. Medicine · 2026Article
- SARS-CoV-2 mRNA Vaccination Induces Reduced T-Cell Apoptosis in Patients with Solid Tumors.International journal of molecular sciences · 2026Article
- Harnessing mucosal immunity for protective vaccines.Nature reviews. Immunology · 2026Review
- Intranasal boosting induces variant-specific responses in SARS-CoV-2 vaccine-imprinted mice.Nature communications · 2026Article
- BPTF is essential for vaccine-induced germinal center B cell responses.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Review
- Respiratory Organ-on-a-Chip for Disease Modeling: From Architecture to Functional Integration.Advanced healthcare materials · 2026Review
- Clonal dynamics of germinal center refueling by secondary immunization.bioRxiv : the preprint server for biology · 2026Article
177 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Update of
Authors and funding
23 authors at 2 institutions in 1 country.
Wooseob Kim *Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-9199-1000
Julian Q Zhou *Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0001-9602-2092
Stephen C HorvathDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Aaron J SchmitzDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-8077-6751
Alexandria J SturtzDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Tingting LeiDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Zhuoming LiuDepartment of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0001-8198-0976
Elizaveta KalaidinaDivision of Allergy and Immunology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA.
Mahima ThapaDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Wafaa B AlsoussiDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Alem HaileClinical Trials Unit, Washington University School of Medicine, St Louis, MO, USA.
Michael K KlebertClinical Trials Unit, Washington University School of Medicine, St Louis, MO, USA.
Teresa SuessenMallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA.
Luis Parra-RodriguezDivision of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA.
Philip A MuddDepartment of Emergency Medicine, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-3860-5473
Sean P J WhelanDepartment of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0003-1564-8590
William D MiddletonMallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA.
Sharlene A TeefeyMallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA.
Iskra PusicDivision of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.
Jane A O'HalloranDivision of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0001-8265-9471
Rachel M PrestiDivision of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-5469-0727
Jackson S TurnerDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Ali H EllebedyDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA. ellebedy@wustl.edu.ORCID http://orcid.org/0000-0002-6129-2532
Washington University in St. Louis · USMallinckrodt (United States) · US
Funding
COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTER: UNIVERSAL INFLUENZA VACCINE RESEARCH75N93019C00051 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KRAMMER, FLORIAN · 2019 to 2025
$105.4MWU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MTRAINING IN THE IMMUNOBIOLOGY AND MOLECULAR CELL BIOLOGY OF CANCERT32CA009547 · NCI · WASHINGTON UNIVERSITY · PI ROBERT DAVID SCHREIBER · 1986 to 2026
$12.1MDYNAMICS AND EVOLUTION OF IMMUNE RESPONSES TO INFLUENZA VIRUSESU01AI150747 · NIAID · EMORY UNIVERSITY · PI AHMED, RAFI, ANTIA, RUSTOM NOSHIR · 2020 to 2024
$5.9MProgramming Durable Immune Responses To VaccinationU01AI141990 · NIAID · WASHINGTON UNIVERSITY · PI Ali Hassan Ellebedy · 2019 to 2026
$5.3MNCATS NIH HHS UL1 TR002345NCI NIH HHS T32 CA009547NIAID NIH HHS 75N93019C00051NIAID NIH HHS HHSN272201400006CNIAID NIH HHS HHSN272201400008CNIAID NIH HHS U01 AI141990NIAID NIH HHS U01 AI150747
Abstract
Germinal centres (GC) are lymphoid structures in which B cells acquire affinity-enhancing somatic hypermutations (SHM), with surviving clones differentiating into memory B cells (MBCs) and long-lived bone marrow plasma cells
Indexed as
B-LymphocytesBNT162 VaccineGerminal CenterVaccinationAntibodies, MonoclonalAntibodies, ViralCOVID-19HumansRNA, MessengerSARS-CoV-2Spike Glycoprotein, CoronavirusAntibodies, MonoclonalAntibodies, ViralBNT162 VaccineRNA, MessengerSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.