Evidence map›Paper›PMID 35167938›Full record

ArticleNeuroscience2022

Differential Expression of Presynaptic Munc13-1 and Munc13-2 in Mouse Hippocampus Following Ethanol Drinking.

Anamitra Ghosh, Sangu Muthuraju, Sean Badal, Jessica Wooden, J Leigh Leasure, Gregg Roman, Joydip Das

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Anamitra GhoshDepartment of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77204, United States.
Sangu MuthurajuDepartment of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77204, United States.
Sean BadalDepartment of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77204, United States.
Jessica WoodenDepartment of Psychology, University of Houston, Houston, TX 77204, United States.
J Leigh LeasureDepartment of Psychology, University of Houston, Houston, TX 77204, United States.
Gregg RomanDepartment of BioMolecular Sciences, University of Mississippi, Oxford, MS 38677, United States.
Joydip DasDepartment of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77204, United States. Electronic address: jdas@uh.edu.
University of Houston · USUniversity of Mississippi · US

Funding

Role of Munc13-1 as a presynaptic effector of ethanol actionR01AA022414 · NIAAA · UNIVERSITY OF HOUSTON · PI DAS, JOYDIP · 2015 to 2019
$1.8M
NIAAA NIH HHS R01 AA022414
6 · The paper itself

Abstract

The Munc13 family of proteins is critically involved in synaptic vesicle priming and release in glutamatergic neurons in the brain. Munc13-1 binds to alcohol and, in Drosophila, modulates sedation sensitivity and self-administration. We examined the effect of alcohol consumption on the expression of Munc13-1 and Munc13-2, NMDA receptor subunits GluN1, GluN2A and GluN2B in the hippocampus-derived HT22 cells, hippocampal primary neuron culture, and wild-type and Munc13-1

Indexed as

Alcohol DrinkingIntracellular Signaling Peptides and ProteinsNerve Tissue ProteinsReceptors, N-Methyl-D-AspartateAnimalsDrosophilaEthanolHippocampusMaleMiceSynaptic TransmissionEthanolIntracellular Signaling Peptides and ProteinsNerve Tissue ProteinsReceptors, N-Methyl-D-AspartateUnc13a protein, mouseUnc13b protein, mousealcohol addictionethanolglutamate receptorshippocampusMunc13neurotransmitterpresynaptic

Identifiers

PMID35167938
PMCPMC8930510
OpenAlexW4210975387

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.