ArticleAmerican journal of respiratory cell and molecular biology2022
eNAMPT Is a Novel Damage-associated Molecular Pattern Protein That Contributes to the Severity of Radiation-induced Lung Fibrosis.
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Article in American journal of respiratory cell and molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
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30 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- Combined antagonism of Oncostatin M (OSM) and Interleukin 6 (IL-6) provides both anti-fibrotic and anti-inflammatory benefit in pulmonary fibrosis.bioRxiv : the preprint server for biology · 2026Article
- Metabolic reprogramming orchestrates microglial fate in cerebral ischemia-reperfusion injury: a spatiotemporal immunometabolic perspective.Frontiers in immunology · 2026Review
- eNAMPT Is a Novel DAMP and Therapeutic Target in Human and Murine Pulmonary Fibrosis.American journal of respiratory cell and molecular biology · 2025Article
- Thirty years of NRF2: advances and therapeutic challenges.Nature reviews. Drug discovery · 2025Review
- NEDD4 E3 ligase-catalyzed NAMPT ubiquitination and autophagy activation are essential for pyroptosis-independent NAMPT secretion in human monocytes.Cell communication and signaling : CCS · 2025Article
- The eNAMPT-Integrin α5β1 Axis Mediates Neutrophil-Endothelial Cell Interactions Driving Inflammation in Ulcerative Colitis.Journal of inflammation research · 2025Article
- Lung-Brain Axis-Generated Inflammatory Biomarkers in Traumatic Brain Injury and Acute Respiratory Distress Syndrome: Role of Mechanical Ventilation/Stress.Advances in biomarker sciences and technology · 2025Article
- Review
- Safety, Tolerability and Pharmacokinetics of the eNAMPT-Neutralizing ALT-100 Mab in Healthy Volunteers.Journal of clinical research and clinical trials · 2024Article
- eNAMPT is a novel therapeutic target for mitigation of coronary microvascular disease in type 2 diabetes.Diabetologia · 2024Article
- Extracellular Nicotinamide Phosphoribosyltransferase Is a Therapeutic Target in Experimental Necrotizing Enterocolitis.Biomedicines · 2024Article
- A Razor's Edge: Vascular Responses to Acute Inflammatory Lung Injury/Acute Respiratory Distress Syndrome.Annual review of physiology · 2024Review
- TLR4 Ligation by eNAMPT, a Novel DAMP, is Essential to Sulfur Mustard- Induced Inflammatory Lung Injury and Fibrosis.European journal of respiratory medicine · 2024Article
- Alveolar Organoids in Lung Disease Modeling.Biomolecules · 2024Review
- An eNAMPT-neutralizing mAb reduces post-infarct myocardial fibrosis and left ventricular dysfunction.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2024Article
- Nicotinamide phosphoribosyltransferase prompts bleomycin-induced pulmonary fibrosis by driving macrophage M2 polarization in mice.Theranostics · 2024Article
- Examination of eQTL Polymorphisms Associated with Increased Risk of Progressive Complicated Sarcoidosis in European and African Descent Subjects.European journal of respiratory medicine · 2023Article
- Overlapping Science in Radiation and Sulfur Mustard Exposures of Skin and Lung: Consideration of Models, Mechanisms, Organ Systems, and Medical Countermeasures: Overlapping science in radiation and sulfur mustard injuries to lung and skin.Disaster medicine and public health preparedness · 2023Article
- Involvement of eNAMPT/TLR4 inflammatory signaling in progression of non-alcoholic fatty liver disease, steatohepatitis, and fibrosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023Article
Corrections and comments
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Authors and funding
22 authors at 4 institutions in 1 country.
Alexander N GarciaDepartment of Radiation Oncology.
Nancy G CasanovaDepartment of Medicine, and.ORCID 0000-0002-6363-2414
Carrie L KempfDepartment of Medicine, and.
Tadeo BermudezDepartment of Medicine, and.
Daniel G ValeraDepartment of Medicine, and.ORCID 0000-0003-4450-4510
Jin H SongDepartment of Medicine, and.ORCID 0000-0002-0123-2909
Xiaoguang SunDepartment of Medicine, and.ORCID 0000-0003-4226-8294
Hua CaiDepartment of Anesthesiology, University of California Los Angeles, Los Angeles, California.
Liliana Moreno-VinascoDepartment of Medicine, and.
Taylor GregoryDepartment of Medicine, and.
Radu C OitaDepartment of Medicine, and.
Vivian Reyes HernonDepartment of Medicine, and.
Sara M CampDepartment of Medicine, and.ORCID 0000-0001-5521-9841
Claude RogersChromoLogic LLC, Monrovia, California; and.
Espoir M KyubwaChromoLogic LLC, Monrovia, California; and.
Naresh MenonChromoLogic LLC, Monrovia, California; and.ORCID 0000-0003-1359-6280
James AxtelleChromoLogic LLC, Monrovia, California; and.
Jay RappaportTulane National Primate Research Center, New Orleans, Louisiana.
Christian BimeDepartment of Medicine, and.ORCID 0000-0003-4787-2685
Saad SammaniDepartment of Medicine, and.ORCID 0000-0002-7933-6388
Anne E CressDepartment of Cell and Molecular Medicine, University of Arizona Health Sciences, Tucson, Arizona.ORCID 0000-0001-6194-0061
Joe G N GarciaDepartment of Medicine, and.ORCID 0000-0002-6934-0420
ChromoLogic (United States) · USTulane University · USUniversity of Arizona · USUniversity of California, Los Angeles · US
Funding
Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4MProtein Chemistry & Biophysics CoreP01HL134610 · NHLBI · UNIVERSITY OF ARIZONA · PI BLACK, STEPHEN M · 2018 to 2022
$11.6MAngiotensin II Uncoupling of Enos in HypertensionR01HL077440 · NHLBI · UNIVERSITY OF CHICAGO · PI CAI, HUA LINDA · 2005 to 2019
$4.8MNOXs, eNOS Uncoupling and Diabetic AtherogenesisR01HL088975 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAI, HUA LINDA · 2010 to 2019
$4.5MTargeting NOX4-dependent mitochondrial dysfunction, autophagy and defective calcium handling in AFR01HL162407 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAI, HUA LINDA, GOLDHABER, JOSHUA I · 2022 to 2025
$2.8MEndothelium-Myocardium Interaction in Netrin-1 Induced CardioprotectionR01HL119968 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAI, HUA LINDA · 2013 to 2017
$2.5MPhenotypes and mechanisms of pulmonary hypertension-driven cognitive impairment and Alzheimer's diseaseR01HL154754 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAI, HUA LINDA, MAKINO, AYAKO · 2020 to 2023
$2.5MeNamptorTM: A Humanized mAb To Reduce the Severity of Radiation Pneumonitis and FibrosisR42HL152888 · NHLBI · AQUALUNG THERAPEUTICS CORP. · PI GARCIA, JOE G. N. · 2020 to 2022
$2.3MNetrin-1 and Netrin-1 Preconditioned EPCs in Vascular ProtectionR01HL142951 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAI, HUA LINDA · 2020 to 2023
$2.0MPathogenic Mechanisms of PBEF in Ventilator Induced Lung InjuryR01HL094394 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GARCIA, JOE G. N. · 2009 to 2012
$1.6MSELPLG as a candidate gene in Acute Respiratory Distress SyndromeK08HL141623 · NHLBI · UNIVERSITY OF ARIZONA · PI BIME, CHRISTIAN · 2018 to 2022
$863kNHLBI NIH HHS K08 HL141623NHLBI NIH HHS P01 HL134610NHLBI NIH HHS R01 HL077440NHLBI NIH HHS R01 HL088975NHLBI NIH HHS R01 HL094394NHLBI NIH HHS R01 HL119968NHLBI NIH HHS R01 HL142951NHLBI NIH HHS R01 HL154754NHLBI NIH HHS R01 HL162407NHLBI NIH HHS R42 HL152888NIH HHS P51 OD011104
Abstract
The paucity of therapeutic strategies to reduce the severity of radiation-induced lung fibrosis (RILF), a life-threatening complication of intended or accidental ionizing radiation exposure, is a serious unmet need. We evaluated the contribution of eNAMPT (extracellular nicotinamide phosphoribosyltransferase), a damage-associated molecular pattern (DAMP) protein and TLR4 (Toll-like receptor 4) ligand, to the severity of whole-thorax lung irradiation (WTLI)-induced RILF. Wild-type (WT) and
Indexed as
Lung InjuryPulmonary FibrosisAlarminsAnimalsAntibodies, MonoclonalCytokinesLungMiceMice, Inbred C57BLNicotinamide PhosphoribosyltransferaseThoraxToll-Like Receptor 4AlarminsAntibodies, MonoclonalCytokinesNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, mouseToll-Like Receptor 4DAMPeNAMPTnicotinamide phosphoribosyltransferaseTLR4whole-lung thoracic irradiation
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.