Evidence map›Paper›PMID 35167321›Full record

ReviewAnnual review of animal biosciences2022

Nonhuman Primates in Translational Research.

Alice F Tarantal, Stephen C Noctor, Dennis J Hartigan-O'Connor

Abstract readReview
In one paragraph

Review in Annual review of animal biosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Trajectory-based weight modeling distinguishes pathologic weight loss and predicts adverse events in nonhuman primate allogeneic kidney transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alice F TarantalDepartments of Pediatrics and Cell Biology and Human Anatomy, University of California, Davis, California, USA; email: aftarantal@ucdavis.edu.
Stephen C NoctorDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, California, USA; email: scnoctor@ucdavis.edu.
Dennis J Hartigan-O'ConnorCalifornia National Primate Research Center, University of California, Davis, California, USA.

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
SCGE Comparative Studies SupplementU42OD027094 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SEGAL, DAVID J · 2019 to 2023
$14.2M
Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood DiseasesR24HL085794 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TARANTAL, ALICE F · 2006 to 2016
$9.7M
UC Davis Biostatistics CoreP01AI131568 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HARTIGAN-O'CONNOR, DENNIS J. · 2017 to 2021
$7.1M
Improved RhCMV/SIV vaccine efficacy via IL-10 pathway modulationR01AI143554 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HARTIGAN-O'CONNOR, DENNIS J. · 2018 to 2022
$4.5M
Developmental Origin and Trafficking of Microglial CellsR01NS109379 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NOCTOR, STEPHEN CHARLES, TARANTAL, ALICE F · 2018 to 2022
$2.6M
PET/CT for Nonhuman Primate ImagingS10RR025063 · NCRR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TARANTAL, ALICE F · 2011 to 2011
$2.1M
Innovative Translational Imaging Technologies to Monitor Genome Edited Cells in VivoUH3EB028910 · NIBIB · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SEGAL, DAVID J, TARANTAL, ALICE F · 2021 to 2022
$935k
Leveraging Established Fetal Primate Models to Expedite ZIKV InvestigationsR21OD023716 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BARRY, PETER A, NOCTOR, STEPHEN CHARLES · 2016 to 2017
$513k
Innovative Translational Imaging Technologies to Monitor Genome Edited Cells in VivoUH2EB028910 · NIBIB · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SEGAL, DAVID J, TARANTAL, ALICE F · 2019 to 2020
$463k
Congenital Zika Syndrome and Postnatal Outcomes in Nonhuman PrimatesR21NS103658 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HARTIGAN-O'CONNOR, DENNIS J., NOCTOR, STEPHEN CHARLES · 2017 to 2018
$425k
Fetal Microglia and NeurogenesisR21NS111313 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NOCTOR, STEPHEN CHARLES, TARANTAL, ALICE F · 2019 to 2019
$425k
NCRR NIH HHS S10 RR025063NHLBI NIH HHS R24 HL085794NIAID NIH HHS P01 AI131568NIAID NIH HHS R01 AI143554NIBIB NIH HHS UH2 EB028910NIBIB NIH HHS UH3 EB028910NIH HHS P51 OD011107NIH HHS R21 OD023716NIH HHS S10 OD016261NIH HHS S10 OD018102NIH HHS U42 OD027094NINDS NIH HHS R01 NS109379NINDS NIH HHS R21 NS103658NINDS NIH HHS R21 NS111313
6 · The paper itself

Abstract

Nonhuman primates are critically important animal models in which to study complex human diseases, understand biological functions, and address the safety of new diagnostics and therapies proposed for human use. They have genetic, physiologic, immunologic, and developmental similarities when compared to humans and therefore provide important preclinical models of human health and disease. This review highlights select research areas that demonstrate the importance of nonhuman primates in translational research. These include pregnancy and developmental disorders, infectious diseases, gene therapy, somatic cell genome editing, and applications of in vivo imaging. The power of the immune system and our increasing understanding of the role it plays in acute and chronic illnesses are being leveraged to produce new treatments for a range of medical conditions. Given the importance of the human immune system in health and disease, detailed study of the immune system of nonhuman primates is essential to advance preclinical translational research. The need for nonhuman primates continues to remain a high priority, which has been acutely evident during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) global pandemic. Nonhuman primates will continue to address key questions and provide predictive models to identify the safety and efficiency of new diagnostics and therapies for human use across the lifespan.

Indexed as

COVID-19PrimatesAnimalsDisease Models, AnimalHumansSARS-CoV-2Translational Research, Biomedicaldevelopmental disordersgene therapyimmune systeminfectious diseasesin vivo imagingpreclinical models

Identifiers

PMID35167321
PMCPMC9339229

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.