Evidence map›Paper›PMID 35167150›Full record

ArticleMolecular microbiology2022

Rv0500A is a transcription factor that links Mycobacterium tuberculosis environmental response with division and impacts host colonization.

Yuzo L Kevorkian, Nathan J MacGilvary, David Giacalone, Calvin Johnson, Shumin Tan

Open access · greenAbstract read
In one paragraph

Article in Molecular microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Rv3839-Rv3840 links the endogenous heme biosynthesis pathway withbioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. TargetingMicrobiology (Reading, England) · 2024
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yuzo L KevorkianDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.
Nathan J MacGilvaryDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.
David GiacaloneDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.
Calvin JohnsonDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.
Shumin TanDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.ORCID 0000-0003-1093-2576
Tufts University · US

Funding

MOLECULAR ANALYSIS OF MICROBIAL PATHOGENST32AI007422 · NIAID · TUFTS UNIVERSITY BOSTON · PI Ralph R. Isberg · 1992 to 2026
$5.7M
MOLECULAR GENETICS OF BASIC CELL FUNCTIONST32GM007310 · NIGMS · TUFTS UNIVERSITY BOSTON · PI CAMILLI, ANDREW · 1987 to 2020
$3.9M
Mycobacterium tuberculosis environmental signal integration: single cell in vivo understanding of its influence on infection heterogeneity and treatment efficacyR01AI143768 · NIAID · TUFTS UNIVERSITY BOSTON · PI TAN, SHUMIN · 2019 to 2023
$3.0M
Bacterial Sensing and Response to Chloride as a Novel Tuberculosis Drug TargetR00AI114952 · NIAID · TUFTS UNIVERSITY BOSTON · PI TAN, SHUMIN · 2016 to 2017
$498k
NIAID NIH HHS R00 AI114952NIAID NIH HHS R01 AI143768NIAID NIH HHS T32 AI007422NIGMS NIH HHS T32 GM007310
6 · The paper itself

Abstract

For Mycobacterium tuberculosis (Mtb) to successfully infect a host, it must be able to adapt to changes in its microenvironment, including variations in ionic signals such as pH and chloride (Cl

Indexed as

Mycobacterium tuberculosisBacterial ProteinsGene Expression Regulation, BacterialPromoter Regions, GeneticTranscription FactorsBacterial ProteinsTranscription Factorschloridegene expression regulationhost-pathogen interactionshydrogen ion concentrationMycobacterium tuberculosistranscription factor

Identifiers

PMID35167150
PMCPMC9382876
OpenAlexW4212960385

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.