Evidence map›Paper›PMID 35167137›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2022

Fast and Cysteine-Specific Modification of Peptides, Proteins and Bacteriophage Using Chlorooximes.

Fa-Jie Chen, Mengmeng Zheng, Vincent Nobile, Jianmin Gao

Open access · greenAbstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Identification of Natural Isonitriles Through Ligation to an Azomethine Imine Probe.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  3. Construction of a Cyclic Peptide Library for Phage Display.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Site-selectiveChemical science · 2024
    Article
  11. Article
  12. Strategies for the Construction of Multicyclic Phage Display Libraries.Chembiochem : a European journal of chemical biology · 2024
    Review
  13. Non-symmetric stapling of native peptides.Nature reviews. Chemistry · 2024
    Review
  14. Construction of Nonnatural Cysteine-Cross-Linked Phage Libraries.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  15. Article
  16. Article
  17. Click chemistry and drug delivery: A bird's-eye view.Acta pharmaceutica Sinica. B · 2023
    Review
  18. Review
  19. Fast Cysteine Bioconjugation Chemistry.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Fa-Jie ChenDepartment of Chemistry Boston College, Merkert Chemistry Center, 2609 Beacon Street, Chestnut Hill, MA 02467, USA.ORCID http://orcid.org/0000-0002-0421-3885
Mengmeng ZhengDepartment of Chemistry Boston College, Merkert Chemistry Center, 2609 Beacon Street, Chestnut Hill, MA 02467, USA.
Vincent NobileDepartment of Chemistry Boston College, Merkert Chemistry Center, 2609 Beacon Street, Chestnut Hill, MA 02467, USA.
Jianmin GaoDepartment of Chemistry Boston College, Merkert Chemistry Center, 2609 Beacon Street, Chestnut Hill, MA 02467, USA.ORCID http://orcid.org/0000-0001-9341-1287
Boston College · US

Funding

Targeted Modification of Membrane LipidsR01GM102735 · NIGMS · BOSTON COLLEGE · PI GAO, JIANMIN · 2012 to 2021
$2.5M
Novel Phage Display Platforms to Overcome Colistin ResistanceR01GM124231 · NIGMS · BOSTON COLLEGE · PI GAO, JIANMIN · 2019 to 2022
$1.2M
Directorate for Mathematical and Physical Sciences CHE-1904874NIGMS NIH HHS GM102735NIGMS NIH HHS R01 GM102735NIGMS NIH HHS R01 GM124231Ono Pharmaceutical
6 · The paper itself

Abstract

This work reports a novel chlorooxime mediated modification of native peptides and proteins under physiologic conditions. This method features fast reaction kinetics (apparent k

Indexed as

BacteriophagesCysteineIndicators and ReagentsPeptidesSulfhydryl CompoundsCysteineIndicators and ReagentsPeptidesSulfhydryl Compoundschlorooximecysteine modificationpeptide staplingphage modificationprotein modification

Identifiers

PMID35167137
PMCPMC8986619
OpenAlexW4212814602

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.