Evidence map›Paper›PMID 35167033›Full record

ArticleImmunologic research2022

Identification of nafamostat mesylate as a selective stimulator of NK cell IFN-γ production via metabolism-related compound library screening.

Qinglan Yang, Shuju Zhang, Shuting Wu, Baige Yao, Lili Wang, Yana Li, Hongyan Peng, Minghui Huang, Qinghua Bi, Peiwen Xiong and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunologic research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. An Overview of Autophagy inFrontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Qinglan YangPediatrics Research Institute of Hunan Province, Hunan Children's Hospital, Changsha, 410007, China.
Shuju ZhangPediatrics Research Institute of Hunan Province, Hunan Children's Hospital, Changsha, 410007, China.
Shuting WuPediatrics Research Institute of Hunan Province, Hunan Children's Hospital, Changsha, 410007, China.
Baige YaoPediatric Intensive Care Unit, Hunan Children's Hospital, University of South China, Changsha, 410007, China.
Lili WangPediatrics Research Institute of Hunan Province, Hunan Children's Hospital, Changsha, 410007, China.
Yana LiPediatrics Research Institute of Hunan Province, Hunan Children's Hospital, Changsha, 410007, China.
Hongyan PengPediatrics Research Institute of Hunan Province, Hunan Children's Hospital, Changsha, 410007, China.
Minghui HuangPediatrics Research Institute of Hunan Province, Hunan Children's Hospital, Changsha, 410007, China.
Qinghua BiInstitute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University), Chongqing, 400038, China.
Peiwen XiongPediatrics Research Institute of Hunan Province, Hunan Children's Hospital, Changsha, 410007, China.
Liping LiPediatrics Research Institute of Hunan Province, Hunan Children's Hospital, Changsha, 410007, China. 13974871993@163.com.
Yafei DengPediatrics Research Institute of Hunan Province, Hunan Children's Hospital, Changsha, 410007, China. yafeideng01@sina.com.
Youcai DengInstitute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University), Chongqing, 400038, China. youcai.deng@tmmu.edu.cn.ORCID http://orcid.org/0000-0001-5488-8576

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural killer (NK) cells play important roles in controlling virus-infected and malignant cells. The identification of new molecules that can activate NK cells may effectively improve the antiviral and antitumour activities of these cells. In this study, by using a commercially available metabolism-related compound library, we initially screened the capacity of compounds to activate NK cells by determining the ratio of interferon-gamma (IFN-γ)

Indexed as

Interleukin-15Leukocytes, MononuclearBenzamidinesGuanidinesInterferon-gammaInterleukin-12Killer Cells, NaturalSimvastatinBenzamidinesGuanidinesInterferon-gammaInterleukin-12Interleukin-15nafamostatSimvastatinIFN-γNafamostat mesylateNatural killer cellStatins

Identifiers

PMID35167033
PMCPMC8852993

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.