Evidence map›Paper›PMID 35166851›Full record

ArticlePain medicine (Malden, Mass.)2022

Pain Burden in the CASiRe International Cohort of Sickle Cell Patients: United States and Ghana.

William T Zempsky, Mary Yanaros, Mohammed Sayeem, Donna Boruchov, Connie M Piccone, Deepa Manwani, Crawford Strunk, Immacolata Tartaglione, Raffaella Colombatti, Sophia Akatue and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pain medicine (Malden, Mass.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

William T ZempskyDepartment of Pediatrics, University of Connecticut School of Medicine, Connecticut Children's Medical Center, Hartford, Connecticut, USA.
Mary YanarosUniversity of Connecticut School of Medicine, Farmington, Connecticut, USA.ORCID 0000-0003-4438-5187
Mohammed SayeemUniversity of Connecticut School of Medicine, Farmington, Connecticut, USA.
Donna BoruchovDepartment of Pediatrics, University of Connecticut School of Medicine, Connecticut Children's Medical Center, Hartford, Connecticut, USA.
Connie M PicconePediatric Hematology/Oncology, Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA.
Deepa ManwaniDepartment of Pediatrics, Albert Einstein College of Medicine, Children's Hospital at Montefiore, Bronx, New York, USA.
Crawford StrunkProMedica Russell J. Ebeid Children's Hospital, Toledo, Ohio, USA.
Immacolata TartaglioneDepartment of Woman, Child and Generalized and Special Surgery, University of Campania "L. Vanvitelli," Naples, Italy.
Raffaella ColombattiDepartment of Women's and Children's Health, University of Padua, Padua, Italy.
Sophia AkatueDivision of Pediatric Hematology/Oncology, University of Michigan, Ann Arbor, Michigan, USA.
Bianca OtengDivision of Pediatric Hematology/Oncology, University of Michigan, Ann Arbor, Michigan, USA.
Ahmed OwdaDivision of Pediatric Hematology/Oncology, University of Michigan, Ann Arbor, Michigan, USA.
Rose BamfoDivision of Pediatric Hematology/Oncology, University of Michigan, Ann Arbor, Michigan, USA.
Samuel WilsonDivision of Pediatric Hematology/Oncology, University of Michigan, Ann Arbor, Michigan, USA.
Angela RiversUCSF Benioff Children's Hospital Oakland, Oakland, California, USA.
Fatimah FarooqDivision of Pediatric Hematology/Oncology, University of Michigan, Ann Arbor, Michigan, USA.
Rebekah UrbonyaDivision of Pediatric Hematology/Oncology, University of Michigan, Ann Arbor, Michigan, USA.
Gifty Dankwah BoatemaaDepartment of Physiology, University of Ghana Medical School, Accra, Ghana.
Sudha RaoDepartment of Child Health, University of Ghana Medical School, Accra, Ghana.
Baba InusaDepartment of Pediatrics, Paediatric Haematology, Guys and St Thomas Hospital, London, UK.
Charles Antwi-BoasiakoDepartment of Physiology, University of Ghana Medical School, Accra, Ghana.
Catherine SegbefiaDepartment of Child Health, University of Ghana Medical School, Accra, Ghana.
Fredericka SeyGhana Institute of Clinical Genetics, Korle Bu Teaching Hospital, Accra, Ghana.
Biree AndemariamNew England Sickle Cell Institute, University of Connecticut Health Center, Farmington, Connecticut, USA.
Eugenia Vicky AsareGhana Institute of Clinical Genetics, Korle Bu Teaching Hospital, Accra, Ghana.
Andrew D CampbellDivision of Pediatric Hematology/Oncology, University of Michigan, Ann Arbor, Michigan, USA.

Funding

University of Michigan Minority Health and Health Disparities International Research Training ProgramT37MD001425 · NIMHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOULTON, MATTHEW LESTER · 2005 to 2025
$4.8M
NIMHD NIH HHS T37 MD001425
6 · The paper itself

Abstract

objectivesSickle Cell Disease (SCD) is a genetic blood disorder affecting over 1 million people globally. The aim of this analysis is to explore the pain burden of patients with SCD in two countries: the United States and Ghana.

methodsThe Consortium for the Advancement of Sickle Cell Research (CASiRe) was created to better understand the clinical severity of patients with SCD worldwide. Data regarding gender, SCD genotype, prior medical diagnoses, and validated pain burden measures were analyzed from the CASiRe database. The Sickle Cell Pain Burden Interview (SCPBI) was used to assess pain burden, the impact of pain on physical, emotional, and social function.

resultsMost subjects identified as Black/African American (n = 298, 97.0%). Patient ages ranged from 6 to 73 years. 35.9% resided in the United States, 64.1% resided in Ghana, 40.9% were men, and 58.7% were women. The mean SCPBI score for US SCD patients was 6.53(±5.89) vs 4.04(±5.10) for Ghanaian patients, P <0.001. Pain burden was higher in US men vs Ghanaian men (6.74(±5.68) vs 3.54(±4.46), P = .003) and in US women vs Ghanaian women (6.37 ± 6.06 vs 4.44(±5.54), P = .032). Pain burden was higher in US patients than Ghanaian patients for both the Hb SC/SBeta+ genotype (5.40(±5.29) vs 2.82(±4.86), P = .054) and Hb SS/SBeta0 genotype (6.79(±6.01) vs 4.49(±5.13), P = .003). Pain burden was significantly higher in SCD patients with comorbid conditions independent of geographic origin including stroke, cholecystectomy, gallstones, depression, and headache. DISCUSSION: US patients with SCD have a higher pain burden than Ghanaian patients. Further studies should investigate underlying contributors to pain burden in these populations and further explore the etiology of geographic differences in pain.

Indexed as

Anemia, Sickle CellStrokeAdolescentAdultAgedChildCohort StudiesFemaleGhanaHumansMaleMiddle AgedPainUnited StatesYoung AdultCASiReChronic PainPain BurdenSickle Cell Disease

Identifiers

PMID35166851
PMCPMC13411743

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.