ArticleThe Plant cell2022
The origin and evolution of a plant resistosome.
Article in The Plant cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Harnessing Natural Diversity and Rational Design for Enhanced Plant Immunity.Plant, cell & environment · 2026Review
- Blue Native-PAGE Assay of NLR Protein Complexes Combined with Genetic Complementation in Nicotiana benthamiana.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Receptor-like cytoplasmic kinases mediated signaling in plant immunity: convergence and divergence.Stress biology · 2025Review
- The resistance awakens: Diversity at the DNA, RNA, and protein levels informs engineering of plant immune receptors from Arabidopsis to crops.The Plant cell · 2025Review
- Phylogenomic analysis reveals exceptions to the co-evolution of ZAR1 and ZRK immune gene families in plants.BMC plant biology · 2025Article
- Soybean genomics research community strategic plan: A vision for 2024-2028.The plant genome · 2024Article
- Activation of plant immunity through conversion of a helper NLR homodimer into a resistosome.PLoS biology · 2024Article
- Bioengineering secreted proteases converts divergent Rcr3 orthologs and paralogs into extracellular immune co-receptors.The Plant cell · 2024Article
- The NRC0 gene cluster of sensor and helper NLR immune receptors is functionally conserved across asterid plants.The Plant cell · 2024Article
- The making of a nucleic acid sensor at the dawn of jawed vertebrate evolution.Science advances · 2024Article
- Revealing the Complete Bispecific Phosphatase Genes (DUSPs) across the Genome and Investigating the Expression Patterns of GH_A11G3500 Resistance againstInternational journal of molecular sciences · 2024Article
- Pattern-Triggered Immunity and Effector-Triggered Immunity: crosstalk and cooperation of PRR and NLR-mediated plant defense pathways during host-pathogen interactions.Physiology and molecular biology of plants : an international journal of functional plant biology · 2024Review
- Plant NLR immunity activation and execution: a biochemical perspective.Open biology · 2024Review
- Jurassic NLR: Conserved and dynamic evolutionary features of the atypically ancient immune receptor ZAR1.The Plant cell · 2023Article
- Tracing the evolution of the ZAR1 resistosome back to the Jurassic era.The Plant cell · 2023Article
- Origin of the OAS-RNase L innate immune pathway before the rise of jawed vertebrates via molecular tinkering.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Overexpression of a Grape MYB Transcription Factor GeneInternational journal of molecular sciences · 2023Article
- An atypical NLR protein modulates the NRC immune receptor network in Nicotiana benthamiana.PLoS genetics · 2023Article
- ATP-citrate lyase B (ACLB) negatively affects cell death and resistance to Verticillium wilt.BMC plant biology · 2022Article
- Inventing the wheel: new insights into resistosome evolution.The Plant cell · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nucleotide-binding, leucine-rich receptor (NLR) protein HOPZ-ACTIVATED RESISTANCE 1 (ZAR1), an immune receptor, interacts with HOPZ-ETI-DEFICIENT 1 (ZED1)-related kinases (ZRKs) and AVRPPHB SUSCEPTIBLE 1-like proteins to form a pentameric resistosome, triggering immune responses. Here, we show that ZAR1 emerged through gene duplication and that ZRKs were derived from the cell surface immune receptors wall-associated protein kinases (WAKs) through the loss of the extracellular domain before the split of eudicots and monocots during the Jurassic period. Many angiosperm ZAR1 orthologs, but not ZAR1 paralogs, are capable of oligomerization in the presence of AtZRKs and triggering cell death, suggesting that the functional ZAR1 resistosome might have originated during the early evolution of angiosperms. Surprisingly, inter-specific pairing of ZAR1 and AtZRKs sometimes results in the formation of a resistosome in the absence of pathogen stimulation, suggesting within-species compatibility between ZAR1 and ZRKs as a result of co-evolution. Numerous concerted losses of ZAR1 and ZRKs occurred in angiosperms, further supporting the ancient co-evolution between ZAR1 and ZRKs. Our findings provide insights into the origin of new plant immune surveillance networks.
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