Evidence map›Paper›PMID 35166563›Full record

ArticlemSystems2022

Phenotypic and Genomic Diversification in Complex Carbohydrate-Degrading Human Gut Bacteria.

Nicholas A Pudlo, Karthik Urs, Ryan Crawford, Ali Pirani, Todd Atherly, Roberto Jimenez, Nicolas Terrapon, Bernard Henrissat, Daniel Peterson, Cherie Ziemer and 2 more

Open access · goldAbstract read
In one paragraph

Article in mSystems, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 86 citations in OpenAlex.

  1. High-throughput analyses ofGut microbes · 2026
    Article
  2. Review
  3. Article
  4. Comparative genomic analysis ofMicrobiology spectrum · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. A system for transferring large genetic loci inApplied and environmental microbiology · 2026
    Article
  10. Article
  11. Article
  12. Degradation of mucinbioRxiv : the preprint server for biology · 2026
    Article
  13. Article
  14. International journal of molecular sciences · 2026
    Article
  15. Comparative Genomic and Functional Profiling of ECM-Targeting Enzymes inbioRxiv : the preprint server for biology · 2026
    Article
  16. Article
  17. Article
  18. Description ofInternational journal of systematic and evolutionary microbiology · 2026
    Article
  19. ExploringmicroLife · 2026
    Article
  20. Importance of human microbiome: an update.Frontiers in microbiomes · 2026
    Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Nicholas A Pudlo *Department of Microbiology and Immunology, University of Michigan Medical Schoolgrid.471406.0, Ann Arbor, Michigan, USA.
Karthik Urs *Department of Microbiology and Immunology, University of Michigan Medical Schoolgrid.471406.0, Ann Arbor, Michigan, USA.
Ryan CrawfordDepartment of Computational Medicine and Bioinformatics, University of Michigan Medical Schoolgrid.471406.0, Ann Arbor, Michigan, USA.
Ali PiraniDepartment of Microbiology and Immunology, University of Michigan Medical Schoolgrid.471406.0, Ann Arbor, Michigan, USA.
Todd AtherlyIowa State University, Department of Animal Science, Ames, Iowa, USA.
Roberto JimenezUniversity of Nebraska, Department of Food Sciences, Lincoln, Nebraska, USA.
Nicolas TerraponAix Marseille Univ, CNRS, UMR7257 AFMB, Marseille, France.
Bernard HenrissatAix Marseille Univ, CNRS, UMR7257 AFMB, Marseille, France.
Daniel PetersonUniversity of Nebraska, Department of Food Sciences, Lincoln, Nebraska, USA.
Cherie ZiemerIowa State University, Department of Animal Science, Ames, Iowa, USA.
Evan SnitkinDepartment of Microbiology and Immunology, University of Michigan Medical Schoolgrid.471406.0, Ann Arbor, Michigan, USA.ORCID 0000-0001-8409-278X
Eric C MartensDepartment of Microbiology and Immunology, University of Michigan Medical Schoolgrid.471406.0, Ann Arbor, Michigan, USA.ORCID 0000-0001-6681-2990
University of Michigan · USCentre National de la Recherche Scientifique · FRUnited States Department of Agriculture · USUniversity of Nebraska–Lincoln · US

Funding

University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OWYANG, CHUNG · 1986 to 2021
$22.5M
Low dietary fiber and gut microbiota-induced mucus layer erosion as IBD triggersR01DK118024 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GRACE Y. CHEN, Eric C Martens · 2018 to 2026
$4.9M
Unraveling the enzymatic pathway of gut bacterial mucus degradation to treat inflammationR01DK125445 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KOROPATKIN, NICOLE M, MARTENS, ERIC C · 2020 to 2023
$2.2M
Complex glycan utilization by human gut BacteroidesK01DK084214 · NIDDK · WASHINGTON UNIVERSITY · PI MARTENS, ERIC C · 2009 to 2013
$584k
NIDDK NIH HHS K01 DK084214NIDDK NIH HHS P30 DK034933NIDDK NIH HHS R01 DK118024NIDDK NIH HHS R01 DK125445
6 · The paper itself

Abstract

Symbiotic bacteria are responsible for the majority of complex carbohydrate digestion in the human colon. Since the identities and amounts of dietary polysaccharides directly impact the gut microbiota, determining which microorganisms consume specific nutrients is central for defining the relationship between diet and gut microbial ecology. Using a custom phenotyping array, we determined carbohydrate utilization profiles for 354 members of the

Indexed as

MicrobiotaPolysaccharidesBacteriaBacteroidesDietary CarbohydratesDietary FiberGenomicsHumansMucinsDietary CarbohydratesDietary FiberMucinsPolysaccharidesBacteroidesmicrobiomepangenomepolysaccharides

Identifiers

PMID35166563
PMCPMC8845570
OpenAlexW4226035475

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.