ArticleThe journal of nutrition, health & aging2022
Frailty Is Associated with Impaired Diabetic Foot Ulcer Healing and All-Cause Re-Hospitalization.
Article in The journal of nutrition, health & aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Frailty score and outcomes of patients undergoing vascular surgery and amputation: A systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2023Pooled it
- Predicting the Path to Attrition: Multidomain Risk Assessment in Diabetic Foot Ulcer Offloading Randomized Controlled Trials.Diabetes care · 2026Trial
- Type 1 diabetes, ageing and frailty: an underexplored intersection.Diabetologia · 2026Review
- Association between frailty progression and clinical outcomes in patients with diabetic foot ulcers.Surgery · 2025Article
- The association of sarcopenia and frailty in diabetes-related foot disease: A 3-year prospective evaluation.Journal of foot and ankle research · 2025Observational
- Decision making in the frail vascular surgery patient: A scoping review.Seminars in vascular surgery · 2024Article
- The Application of Digital Frailty Screening to Triage Nonhealing and Complex Wounds.Journal of diabetes science and technology · 2024Article
- Predictive Strategies to Reduce the Risk of Rehospitalization with a Focus on Frail Older Adults: A Narrative Review.Epidemiologia (Basel, Switzerland) · 2023Review
- Prognostic factors for delayed healing of complex wounds in adults: A scoping review.International wound journal · 2023Article
- Detection, management, and prevention of diabetes-related foot disease in the Australian context.World journal of diabetes · 2023Review
- Venous, Arterial, and Neuropathic Leg Ulcers With Emphasis on the Geriatric Population.Cureus · 2023Review
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Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetic Foot Ulcers (DFUs) are a common and feared complication of type 1 and type 2 diabetes. People with DFUs often present a significant clinical complexity due to multimorbidity, frailty, polypharmacy, and disabling conditions. Frailty, defined using the accumulation of health deficits model, has shown to predict worsening health status, hospitalizations, and death in older persons. There are no clinical studies, to date, that have examined the prevalence and effect of frailty on DFUs outcomes. The aim of our study was to explore the impact of frailty on DFUs healing and re-hospitalization in a cohort of patients hospitalized with DFUs.
designprospective cohort study. SETTING AND
participantsThe frailty status of 76 consecutive hospitalized patients with DFUs was assessed by using the Frailty Index (FI). MEASUREMENTS: The primary outcome was the non-healing of the DFU. Secondary outcome was re-hospitalization events (for any cause) within 6 months from hospital discharge. Frailty was defined as FI>0.25.
resultsOut of 76 patients (median age 65 years, range 31-84), 56 (74%) were frail. At six months, 81.5% of frail patients had non-healing of the DFU compared to 55% in non-frail patients (p=0.02). The rate of of re-hospitalization was also higher in frail compared to non-frail (90.3% vs 54%, respectively; p=0.01) patients. In multivariable analyses, frailty was significantly associated with a more than fivefold increased risk of DFU non-healing [odds ratio 5.54 (95% confidence interval 1.28-23.91), p=0.02]. Similarly, re-hospitalization was also significantly higher in frail patients compared to the non-frail ones.
conclusionsIn hospitalized patients with DFUs, frailty was highly prevalent. Frailty emerged as an independent risk factor for DFU non-healing and re-hospitalization events. Patients with DFUs require a comprehensive assessment of their frailty status which would enable personalization of their management and interventions.
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