ArticleBiomedical journal2021
Modification of brain waves and sleep parameters by Citrus reticulata Blanco. cv. Sai-Nam-Phueng essential oil.
Article in Biomedical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- fNIRS neuroimaging in olfactory research: A systematic literature review.Frontiers in behavioral neuroscience · 2022Pooled it
- EEG-Based Neurophysiological Assessment of Pharmacopoeial-Quality Essential Oils and Development of Stable Micro-Emulsion Systems for Aromatherapy Applications.Pharmaceuticals (Basel, Switzerland) · 2026Article
- A Novel Functional Ingredient Derived From a Mixture of Mulberry (Oxidative medicine and cellular longevity · 2026Article
- Dose-dependent responses: a preliminary investigation into the olfactory effects of essential oil concentrations on canine behavior.Veterinary research communications · 2024Article
- Real-world observations and impacts of Chinese herbal medicine for migraine: results of a registry-based cohort study.Frontiers in pharmacology · 2024Article
- Management of long-COVID-19 patients with sleep disorders: practical advice to general practitioners.The Libyan journal of medicine · 2023Article
- Citrus By-Products as a Valuable Source of Biologically Active Compounds with Promising Pharmaceutical, Biological and Biomedical Potential.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Electronic Nose and Head Space GC-IMS Provide Insights into the Dynamic Changes and Regularity of Volatile Compounds in Zangju (Molecules (Basel, Switzerland) · 2023Article
- Citrus Essential Oils in Aromatherapy: Therapeutic Effects and Mechanisms.Antioxidants (Basel, Switzerland) · 2022Review
- Nanoencapsulation of Mandarin Essential Oil: Fabrication, Characterization, and Storage Stability.Foods (Basel, Switzerland) · 2021Article
- After me, the deluge: The intricacies of pulmonary surfactant.Biomedical journal · 2021Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCitrus essential oil (EO) has been used for mood elevation and sedative hypnotic purposes. However, scientific proofs of its central nervous system (CNS) action remained largely unexplored. This study investigated chemotypes, electrical brain waves and sleep-wake effects of the essential oil from Citrus reticulata in rat model.
methodsChemical contents of citrus EO were analyzed using gas chromatography-mass spectrometry (GC-MS). Male Wistar rats implanted with electrodes on the frontal and parietal skulls were used for electroencephalographic (EEG) recording while inhaling the citrus EO (200 μl on cotton wool). Diazepam (10 mg/kg, p.o.) was used as a standard anxiolytic drug. EEG frequency analyses were performed by using Fast Fourier transform. All data were statistical analyzed using One-way ANOVA followed by Tukey's test.
resultsGC-MS analysis revealed d-limonene (95.7%) as a major constituent of citrus EO. The EEG results showed that overall EEG patterns of citrus EO effects were relatively similar to that of diazepam. However, significant differences between treatments were seen from sleep-wake analyses. Diazepam significantly increased episode numbers of awake and non-rapid eye movement (REM) sleep and reduced averaged episode duration. On the other hand, the citrus EO significantly decreased REM sleep latency and increased total time and episode numbers of REM sleep.
conclusionThese findings demonstrated unique CNS effects of C. reticulata EO with EEG fingerprints and sleep-wake profiles. The data might be useful for citrus essential oil sub-classification and clinical application.
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