ArticleBrain and behavior2022
Interhemispheric functional connectivity asymmetry is distinctly affected in left and right mesial temporal lobe epilepsy.
Article in Brain and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hemispheric asymmetries in rodent models of neurological diseases: a systematic review.Frontiers in integrative neuroscience · 2026Pooled it
- Network reorganization of anterograde thalamic connectivity during non-periodic patterned deep brain stimulation.iScience · 2026Article
- Quantitative Electroencephalographic (qEEG) Characterisation and Biomarker Identification of Generalised Paediatric Seizure Using Spectral Features.Annals of neurosciences · 2026Article
- Commonalities and distinctions of static and dynamic functional connectivity density between left and right temporal lobe epilepsy.Scientific reports · 2026Article
- Transcranial Focused Ultrasound Stimulation Targeting White Matter Inhibits Seizures in a Rat Model of Epilepsy.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026Article
- Metabolic connectivity and memory in mesial temporal lobe epilepsy.Brain communications · 2026Article
- Examining Brain Function Changes in HIV-Infected Patients With Asymptomatic Neurocognitive Impairment: A Longitudinal Study.Brain and behavior · 2025Article
- Altered correlation of concurrently recorded EEG-fMRI connectomes in temporal lobe epilepsy.Network neuroscience (Cambridge, Mass.) · 2024Article
- Interhemispheric functional connectivity asymmetry is distinctly affected in left and right mesial temporal lobe epilepsy.Brain and behavior · 2022Article
- Distinct limbic connectivity in left and right benign mesial temporal lobe epilepsy: Evidence from a resting state functional MRI study.Frontiers in neurology · 2022Article
- The decreased connectivity in middle temporal gyrus can be used as a potential neuroimaging biomarker for left temporal lobe epilepsy.Frontiers in psychiatry · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe differences of functional connectivity (FC) and functional asymmetry between left and right mesial temporal lobe epilepsy with hippocampal sclerosis (LMTLE and RMTLE) have not been completely clarified yet. The purpose of the present study is to investigate the FC changes and the FC asymmetric patterns of MTLE, and to compare the differences in FC and functional asymmetry between LMTLE and RMTLE.
methodsIn total, 12 LMTLE, 11 RMTLE patients, and 23 healthy controls (HC) were included. Region of interest (ROI)-based analysis was used to evaluate FC. The right functional connectivity (rFC) and left functional connectivity (lFC) of each ROI were calculated. Asymmetry index (AI) was calculated based on the following formula:
resultsLMTLE and RMTLE patients showed different patterns of alteration in FC and functional asymmetry when compared with controls. RMTLE presented more extensive FC abnormalities than LMTLE. Regions in ipsilateral temporal lobe presented as central regions of abnormalities in both patient groups. In addition, the asymmetric characteristics of FC were reduced in MTLE compared with HC, with even more pronounced reduction for RMTLE group. Meanwhile, ROIs presented FC AI differences among the three groups were mostly involving left temporal lobe (L_hippo, L_amyg, L_TP, L_aMTG, and L_pTFusC). No correlation was found between significant FC changes and lateralized ROIs and epilepsy onset age and duration.
conclusionThe FC and asymmetric features of MTLE are altered and involve both the temporal lobe and extra-temporal lobe. Furthermore, the altered FC and asymmetric features were distinctly affected in LMTLE and RMTLE compared to controls.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.