Evidence map›Paper›PMID 35165954›Full record

ArticleJournal of neuroendocrinology2022

ENETS standardized (synoptic) reporting for neuroendocrine tumour pathology.

Marie-Louise F van Velthuysen, Anne Couvelard, Guido Rindi, Nicola Fazio, Dieter Hörsch, Els J Nieveen van Dijkum, Günter Klöppel, Aurel Perren

Open access · hybridAbstract read
In one paragraph

Article in Journal of neuroendocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Guideline
  2. Review
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  4. Step-by-Step Approach to the Incidental Diagnosis of Type I Gastric Neuroendocrine Tumors: Practical Insights.JGH open : an open access journal of gastroenterology and hepatology · 2025
    Review
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 8 institutions in 5 countries.

Marie-Louise F van VelthuysenDepartment Pathology, Erasmus MC, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0003-0435-9494
Anne CouvelardService de Pathologie, Hôpital Bichat AP-HP et Université de Paris, Paris, France.ORCID https://orcid.org/0000-0002-6316-1210
Guido RindiSection of Anatomic Pathology, Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Roma, Italia.ORCID https://orcid.org/0000-0003-2996-4404
Nicola FazioDivision of gastrointestinal medical oncology and neuroendocrine tumors, European Institute of Oncology (IEO), IRCCS, Milan, Italy.ORCID https://orcid.org/0000-0001-6869-0704
Dieter HörschCA Gastroenterologie, Zentralklinik Bad Berka GmbH, Bad Berka, Germany.
Els J Nieveen van DijkumDepartment of Surgery, Cancer Centre Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0002-3029-6071
Günter KlöppelDepartment of Pathology, Consultation Center for Pancreatic and Endocrine Tumors, TU Munich, Munich, Germany.ORCID https://orcid.org/0000-0002-6688-086X
Aurel PerrenInstitute of Pathology, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0002-6819-6092
AMS (Germany) · DEAmsterdam University Medical Centers · NLErasmus MC · NLEuropean Institute of Oncology · ITUniversità Cattolica del Sacro Cuore · ITUniversité Paris Cité · FRUniversity of Bern · CHZentralklinik Bad Berka · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years the WHO classification of neuroendocrine neoplasms (NEN) has evolved. Nomenclature as well as thresholds for grading have changed leading to potential confusion and lack of comparability of tumour reports. Therefore, the European Neuroendocrine Tumour Society (ENETS) has set-up an interdisciplinary working group to develop templates for a pathology data set for standardised reporting of NEN. Experts of various disciplines, members of the ENETS Advisory Board, formed a taskforce that discussed and decided on the structure, content and the number of templates needed for reporting the most common NEN. The selection of the required items was based on the WHO classification of digestive system tumours, the WHO classification of tumours of the lung and mediastinum and on "ENETS standard of care" reports. The final proposal of the working group was approved by the ENETS Advisory Board. Templates for synoptic reporting were created for the seven most common NEN primary sites, that is, stomach, duodenum, jejunum-ileum, appendix, colon-rectum, pancreas, lung and mediastinum. In addition, a general template for reporting biopsies was designed. The templates allow the recording of the essential items on differentiation, proliferation (Ki-67 and mitosis), neuroendocrine features (positivity for chromogranin A and synaptophysin) and stage as well as several optional markers especially helpful for the distinction of neuroendocrine tumours (NET) from neuroendocrine carcinomas (NEC). In summary, this paper presents the content and development of synoptic reports for most sites of NEN by a multidisciplinary team of international experts in the field, which could help to improve unambiguous reporting of NEN.

Indexed as

Neuroendocrine TumorsHumansNeurosecretory SystemsNECNETneuro endocrine neoplasmpathology reportsynoptic report

Identifiers

PMID35165954
PMCPMC9285411
OpenAlexW4210441716

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.