Evidence map›Paper›PMID 35165938›Full record

ArticleJournal of veterinary internal medicine2022

Diarrhea outbreak associated with coronavirus infection in adult dairy goats.

Fauna Leah Smith, Meera C Heller, Beate M Crossley, Kristin A Clothier, Mark L Anderson, Samantha S Barnum, Nicola Pusterla, Joan D Rowe

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Fauna Leah SmithGraduate Group in Integrative Pathobiology, Center for Immunology and Infectious Disease, University of California, Davis, Davis, California, USA.ORCID https://orcid.org/0000-0001-5535-7726
Meera C HellerDepartment of Medicine and Epidemiology, University of California Davis School of Veterinary Medicine, Davis, California, USA.ORCID https://orcid.org/0000-0002-0080-5736
Beate M CrossleyDepartment of Medicine and Epidemiology, University of California Davis School of Veterinary Medicine, Davis, California, USA.
Kristin A ClothierCalifornia Animal Health and Food Safety Laboratory System, Davis, California, USA.
Mark L AndersonCalifornia Animal Health and Food Safety Laboratory System, Davis, California, USA.
Samantha S BarnumSchool of Veterinary Medicine, University of California, Davis, California, USA.
Nicola PusterlaDepartment of Medicine and Epidemiology, University of California Davis School of Veterinary Medicine, Davis, California, USA.
Joan D RoweDepartment of Population, Health & Reproduction, University of California, Davis, California, USA.
University of California, Davis · USWest Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInfection by coronaviruses cause gastrointestinal disease in many species. Little is known about its prevalence and importance in goats.

objectiveIdentify the etiology, demographics, and clinical features of an outbreak of diarrhea in adult goats. HYPOTHESIS: Bovine coronavirus (BCoV) PCR would detect viral material in feces of goats in the herds involved in the diarrhea outbreak. ANIMALS: Twelve herds with 4 to 230 adult goats were affected. Goats sampled for fecal PCR were ≥1-year-old: 25 from affected herds and 6 from a control herd.

methodsThis is a cross-sectional descriptive study of an outbreak of diarrheal disease in adult goats. BCoV PCR primers for the spike (S) or nucleocapsid (N) proteins were used to test fecal material from affected goats. The N protein sequencing and phylogenetic analysis was performed. Herd records and owner surveys were used to characterize morbidity, clinical signs, and treatment.

resultsIn 2 affected herds 18/25 of animals had at least 1 positive BCoV PCR test. Goats from affected herds were significantly more likely to be PCR positive than the control herd (OR 8.75, 95% CI 1.11-104, P = .05). The most common clinical signs were change in fecal consistency (19/20) and decreased milk production (14/15). Phylogenetic analysis of the N protein showed this virus was closely related to a bovine-like coronavirus isolated from a giraffe. CONCLUSIONS AND CLINICAL IMPORTANCE: Bovine coronavirus primers detected nucleic acids of the N and S proteins in feces of goats in affected herds. Coronavirus shedding frequency was temporally associated with the outbreak.

Indexed as

Cattle DiseasesCoronavirus InfectionsGoat DiseasesAnimalsCattleCross-Sectional StudiesDiarrheaDisease OutbreaksFecesGoatsPhylogenycaprineinfectious diseasePCR assaysviral disease

Identifiers

PMID35165938
PMCPMC8965271
OpenAlexW4212936621

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.