Observational studyActa psychiatrica Scandinavica2022
Clinical and societal burden of incident major depressive disorder: A population-wide cohort study in Stockholm.
Observational study in Acta psychiatrica Scandinavica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Efficacy of a Cognitive Behavioral Therapy-Based Online Self-Help Group for Depression and Suicide Ideation: Randomized Controlled Trial.JMIR mHealth and uHealth · 2026Trial
- Long-Term Effectiveness of Unguided Internet-Based Cognitive Behavioral Therapy on Major Depressive Disorder in Chinese Adults: Randomized Controlled Trial With a 12-Month Follow-Up.JMIR mHealth and uHealth · 2026Trial
- Central nervous system acting medication used by young adults with borderline personality disorder in Sweden 2006-2019.Journal of psychopharmacology (Oxford, England) · 2026Article
- Mixed features and suicide attempts in youth depression: a six-month follow-up study.BMC psychiatry · 2026Article
- Metabolic risk stratification and psychotic symptoms in first-episode drug-naïve major depressive disorder: a principal component-based cross-sectional study.Frontiers in psychiatry · 2026Article
- Article
- Association of Treatment-Resistant Depression With Patient Outcomes and Health Care Resource Utilization in a Population-Wide Study.JAMA psychiatry · 2023Observational
- Practical pathway for the management of depression in the workplace: a Canadian perspective.Frontiers in psychiatry · 2023Review
- Incidence and Factors Associated with Hyperglycemia in Patients with First Hospitalization for Major Depression Disorder: A Large Cross-Sectional Sample.Neuropsychiatric disease and treatment · 2023Article
- Clinical and societal burden of incident major depressive disorder: A population-wide cohort study in Stockholm.Acta psychiatrica Scandinavica · 2022Observational
Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMajor depressive disorder (MDD) is a highly prevalent condition and a significant contributor to global disability. The vast majority of MDD is handled by primary care, but most real-life studies on MDD only include data from secondary care. The aim of this study was therefore to estimate the total clinical and societal burden of incident MDD including data from all healthcare levels in a large well-defined western European healthcare region.
methodsPopulation-wide observational study included healthcare data from Region Stockholm, Sweden's largest region with approximately 2.4 million inhabitants. All patients in Region Stockholm having their first unipolar MDD episode between January 1, 2012, and December 31, 2018, were included. The sample also included matched study population controls. Outcomes were psychiatric and non-psychiatric comorbid conditions, antidepressant therapy use, healthcare resource utilization, work loss, and all-cause mortality.
resultsIn the study period, 137,822 patients in Region Stockholm were diagnosed with their first unipolar MDD episode. Compared with matched controls, MDD patients had a higher burden of non-psychiatric and psychiatric comorbid conditions, 3.2 times higher outpatient healthcare resource utilization and 8.6 times more work loss. MDD was also associated with a doubled all-cause mortality compared with matched controls (HR: 2.2 [95% CI: 2.0-2.4]).
conclusionsThe high mortality, morbidity, healthcare resource utilization, and work loss found in this study confirms that MDD is associated with individual suffering and low functioning leading to substantial costs for patients and society. These findings should motivate additional efforts in improving outcomes for MDD patients.
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