Evidence map›Paper›PMID 35165858›Full record

ArticleHuman cell2022

MiR-1260b protects against LPS-induced degenerative changes in nucleus pulposus cells through targeting TCF7L2.

Shijie Chen, Guixia Shi, Jin Zeng, Ping Huang Li, Yi Peng, Zhiyu Ding, Hong Qing Cao, Ruping Zheng, Weiguo Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Human cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Shijie ChenDepartment of Orthopaedics, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China.
Guixia ShiDepartment of Internal Medicine, Changsha Health Vocational Collage, Changsha, 410100, Hunan, China.
Jin ZengDepartment of Orthopaedics, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China.
Ping Huang LiDepartment of Orthopaedics, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China.
Yi PengDepartment of Orthopaedics, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China.
Zhiyu DingDepartment of Orthopaedics, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China.
Hong Qing CaoDepartment of Orthopaedics, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China.
Ruping ZhengSchool of Basic Medical Science, Central South University, Changsha, 410013, Hunan, China.
Weiguo WangDepartment of Orthopaedics, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China. csuwwg@csu.edu.cn.
Central South University · CNThird Xiangya Hospital · CNChangsha Hospital for Maternal and Child Health Care · CNEast China Normal University · CN

Funding

National Natural Science Foundation of China No. 81502331National Natural Science Foundation of China No. 81772866Natural Science Foundation of Hunan Province 2021JJ31025
6 · The paper itself

Abstract

Nucleus pulposus (NP) cells play a critical role in maintaining intervertebral disc integrity through producing the components of extracellular matrix (ECM). NP cell dysfunction, including senescence and hyper-apoptosis, has been regarded as critical events during intervertebral disc degeneration development. In the present study, we found that Transcription Factor 7-Like 2 (TCF7L2) was overexpressed within degenerative intervertebral disc tissue samples, and TCF7L2 silencing improved lipopolysaccharide (LPS)-induced repression on NP cell proliferation, ECM synthesis, and LPS-induced NP cell senescence. miR-1260b directly targeted TCF7L2 and inhibited TCF7L2 expression. miR-1260b overexpression improved LPS-induced degenerative changes in NP cells; more importantly, TCF7L2 overexpression significantly reversed the effects of miR-1260b overexpression on LPS-stimulated degenerative changes within NP cells. For the first time, we demonstrated the function of the miR-1260b/TCF7L2 axis on the phenotypic maintenance of chondrocyte-like NP cells and ECM synthesis by NP cells under LPS stimulation.

Indexed as

Intervertebral Disc DegenerationMicroRNAsNucleus PulposusApoptosisCells, CulturedExtracellular MatrixHumansLipopolysaccharidesTranscription Factor 7-Like 2 ProteinLipopolysaccharidesMicroRNAsMIRN1260 microRNA, humanTCF7L2 protein, humanTranscription Factor 7-Like 2 ProteinIntervertebral disc degenerationmiR-1260bNucleus pulposus cellsSenescenceTCF7L2

Identifiers

PMID35165858
OpenAlexW4212994070

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.