Evidence map›Paper›PMID 35165808›Full record

ArticleInflammopharmacology2022

In vitro and in vivo anti-inflammatory and anticoagulant activities of Myrciaria plinioides D. Legrand ethanol leaf extract.

Diorge Jônatas Marmitt, Shanna Bitencourt, Chistiane Oliveira Coura, Markus Berger, Dalana Faleiro, Débora Mara Kich, Bruna Caye, Sheila Mariele Immich, Annyta Fernandes Frota, Walter O Beys-da-Silva and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inflammopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Diorge Jônatas MarmittLaboratório de Cultura de Células, Programa de Pós-Graduação em Biotecnologia, Universidade do Vale do Taquari-Univates, Lajeado, Brazil.
Shanna BitencourtLaboratório de Cultura de Células, Programa de Pós-Graduação em Biotecnologia, Universidade do Vale do Taquari-Univates, Lajeado, Brazil.
Chistiane Oliveira CouraDepartamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará (UFC), Fortaleza, Brazil.
Markus BergerLaboratório de Bioquímica Farmacológica, Centro de Pesquisa Experimental, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul (CPE-HCPA/UFRGS), Porto Alegre, Brazil.
Dalana FaleiroLaboratório de Cultura de Células, Programa de Pós-Graduação em Biotecnologia, Universidade do Vale do Taquari-Univates, Lajeado, Brazil.
Débora Mara KichLaboratório de Cultura de Células, Programa de Pós-Graduação em Biotecnologia, Universidade do Vale do Taquari-Univates, Lajeado, Brazil.
Bruna CayeLaboratório de Cultura de Células, Programa de Pós-Graduação em Biotecnologia, Universidade do Vale do Taquari-Univates, Lajeado, Brazil.
Sheila Mariele ImmichLaboratório de Cultura de Células, Programa de Pós-Graduação em Biotecnologia, Universidade do Vale do Taquari-Univates, Lajeado, Brazil.
Annyta Fernandes FrotaDepartamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará (UFC), Fortaleza, Brazil.
Walter O Beys-da-SilvaLaboratório de Bioquímica Farmacológica, Centro de Pesquisa Experimental, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul (CPE-HCPA/UFRGS), Porto Alegre, Brazil.
Jorge Almeida GuimarãesLaboratório de Bioquímica Farmacológica, Centro de Pesquisa Experimental, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul (CPE-HCPA/UFRGS), Porto Alegre, Brazil.
Norma Maria Barros BenevidesDepartamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará (UFC), Fortaleza, Brazil.
Stefan LauferDepartment of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, University of Tübingen, Tübingen, Germany.
Márcia Inês GoettertLaboratório de Cultura de Células, Programa de Pós-Graduação em Biotecnologia, Universidade do Vale do Taquari-Univates, Lajeado, Brazil. marcia.goettert@univates.br.ORCID http://orcid.org/0000-0002-3648-5033
Univates · BRUniversidade Federal do Ceará · BRUniversidade Federal do Rio Grande do Sul · BRUniversity of Tübingen · DE

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico Edital MCTI/CNPq No. 14/2014Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Finance Code 001
6 · The paper itself

Abstract

Myrciaria plinioides D. Legrand (Myrtaceae) is a native plant of Southern Brazil, which have potential in the food industry due to its edible fruits. Many plants belonging to this genus have been used for a variety of illnesses, including inflammatory disorders due to antioxidant properties. However, therapeutic uses of M. plinioides have been poorly studied. The aim of study was to assess the anti-inflammatory and anticoagulant activities of the ethanol leaf extract of M. plinioides. In M. plinioides extract-treated RAW 264.7 cells, assessments of cell viability, TNF-α release and p38 MAPK pathway-dependent protein expression were detected. In addition, rat paw edema models were used to analyze the anti-inflammatory effect of the extract. Macrophages cell line treated with M. plinioides extract showed a slight decrease in cell viability. In LPS-stimulated macrophages treated with different concentrations of the extract for 24 h, TNF-α release was inhibited, while modulation of p38 signaling pathway and inhibition of NF-κB p65 protein expression were dose-dependent. In rats, the extract inhibited the formation of paw edema, while an inhibitory effect on trypsin-like enzymes derived from mast cells was seen. Furthermore, the extract presented anticoagulant activity via extrinsic pathway, being able to block specifically factor Xa and thrombin. The study suggests that extract possess potent anti-inflammatory and anticoagulant effects. M. plinioides present great biological potential as a source for the development of anti-inflammatory and anticoagulant drugs. Additional studies can be proposed to better elucidate the mechanism by which M. plinioides exerts its effects.

Indexed as

EthanolMyrtaceaeAnimalsAnticoagulantsAnti-Inflammatory AgentsLipopolysaccharidesNF-kappa BNitric OxidePlant ExtractsRatsAnticoagulantsAnti-Inflammatory AgentsEthanolLipopolysaccharidesNF-kappa BNitric OxidePlant ExtractsAnticoagulantAnti-inflammatory activityExtrinsic pathwayMyrciaria plinioidesp38 signaling pathwayRat model

Identifiers

PMID35165808
PMCPMC8948148
OpenAlexW4226051290

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.