Evidence map›Paper›PMID 35165788›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2022

Imaging of neuroinflammation due to repetitive head injury in currently active kickboxers.

Gilles N Stormezand, Janine Doorduin, Sandra E Rakers, Jacoba M Spikman, Joukje van der Naalt, David Vállez García, Anouk van der Hoorn, Chris W J van der Weijden, Berry P H Kremer, Remco J Renken and 1 more

Erratum issuedOpen access · hybridAbstract read
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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Gilles N StormezandDepartment of Nuclear Medicine and Molecular Imaging, Medical Imaging Center, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands. g.n.stormezand01@umcg.nl.ORCID 0000-0002-1370-8791
Janine DoorduinDepartment of Nuclear Medicine and Molecular Imaging, Medical Imaging Center, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.
Sandra E RakersDepartment of Clinical Neuropsychology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Jacoba M SpikmanDepartment of Clinical Neuropsychology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Joukje van der NaaltDepartment of Neurology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
David Vállez GarcíaDepartment of Nuclear Medicine and Molecular Imaging, Medical Imaging Center, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.
Anouk van der HoornDepartment of Radiology, Medical Imaging Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Chris W J van der WeijdenDepartment of Nuclear Medicine and Molecular Imaging, Medical Imaging Center, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.
Berry P H KremerDepartment of Neurology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Remco J RenkenCognitive Neuroscience Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Rudi A J O DierckxDepartment of Nuclear Medicine and Molecular Imaging, Medical Imaging Center, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands.
University Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeChronic traumatic encephalopathy refers to a neurodegenerative disease resulting from repetitive head injury of participants in contact sports. Similar to other neurodegenerative diseases, neuroinflammation is thought to play a role in the onset and progression of the disease. Limited knowledge is available regarding the neuroinflammatory consequences of repetitive head injury in currently active contact sports athletes. PET imaging of the 18-kDa translocator protein (TSPO) allows quantification of microglial activation in vivo, a marker of neuroinflammation.

methodsEleven rank A kickboxers and 11 age-matched controls underwent TSPO PET using [

resultsOn a group level, no statistically significant differences were detected in non-displaceable binding potential (BP

conclusionDespite negative results on a group level, individual results suggest that neuroinflammation may be present as a consequence of repetitive head injury in active kickboxers. Future studies using a longitudinal design may determine whether the observed TSPO upregulation is related to the future development of neuropsychiatric symptoms.

Indexed as

Athletic InjuriesCraniocerebral TraumaNeurodegenerative DiseasesNeuroinflammatory DiseasesBrainDiffusion Tensor ImagingHumansMartial ArtsPositron-Emission TomographyReceptors, GABAReceptors, GABATSPO protein, humanKickboxersNeuroinflammationRepetitive head injuryTSPO PET

Identifiers

PMID35165788
PMCPMC9250484
OpenAlexW4221004077

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.