Evidence map›Paper›PMID 35165581›Full record

ArticleCureus2022

Association Between Serum Magnesium and Glycemic Control, Lipid Profile and Diabetic Retinopathy in Type 1 Diabetes.

Isabel Inácio, Teresa Azevedo, Ana Margarida Balsa, Sara Ferreira, Patrícia Rosinha, Márcia Alves, Rosa Dantas, Joana Guimarães

Open access · diamondAbstract read
In one paragraph

Article in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Isabel InácioEndocrinology Department, Centro Hospitalar do Baixo Vouga, Aveiro, PRT.
Teresa AzevedoEndocrinology Department, Centro Hospitalar do Baixo Vouga, Aveiro, PRT.
Ana Margarida BalsaEndocrinology Department, Centro Hospitalar de Trás-Os-Montes E Alto Douro, Vila Real, PRT.
Sara FerreiraEndocrinology Department, Centro Hospitalar do Baixo Vouga, Aveiro, PRT.
Patrícia RosinhaEndocrinology Department, Centro Hospitalar do Baixo Vouga, Aveiro, PRT.
Márcia AlvesEndocrinology Department, Centro Hospitalar do Baixo Vouga, Aveiro, PRT.
Rosa DantasEndocrinology Department, Centro Hospitalar do Baixo Vouga, Aveiro, PRT.
Joana GuimarãesEndocrinology Department, Centro Hospitalar do Baixo Vouga, Aveiro, PRT.
Centro Hospitalar do Baixo Vouga · PTCentro Hospitalar de Trás os Montes e Alto Douro · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMany studies have shown an association between decreased serum magnesium (Mg) levels and poor glycemic control and dyslipidemia in individuals with type 1 diabetes (T1D). Few studies evaluated the association between magnesium (Mg) levels and diabetic retinopathy (DR) in individuals with type 1 diabetes (T1D).

methodsRetrospective study of adults with T1D, with an ophthalmological evaluation and a serum Mg level determination. According to Mg levels, the individuals were stratified into two groups: normal Mg levels (1.81-2.60 mg/dL) and low Mg levels (≤1.80 mg/dL). Exclusion criteria were individuals on diuretics or proton-pump inhibitors, malabsorption or diarrhea, oral magnesium supplementation in the recent past, pregnancy, or sepsis.

results105 individuals, with median Mg levels of 1.96 (interquartile range 0.23) mg/dL. Hypomagnesemia (≤1.80 mg/dL) was detected in 20.0% individuals and 26.7% had DR. Individuals with hypomagnesemia had higher HbA1c (p = 0.014) and triglycerides (p = 0.024). Mg levels were negatively correlated with systolic blood pressure (r = -0.200, p = 0.041), HbA1c (r = -0.281, p = 0.004) and body mass index (BMI) (r = -0.197, p = 0.041). There was no significant difference between Mg levels or prevalence of hypomagnesemia in individuals with or without DR. Also, there was no significant difference between Mg levels and the severity of DR.

conclusionHypomagnesemia is a common problem in adults with T1D, and it was correlated with poor glycemic control, although we did not find a significant association between Mg levels and prevalence or severity of DR.

Indexed as

diabetic retinopathydrdyslipidemiaglycemic controlhypomagnesemiamagnesiummgserum magnesiumtype 1 diabetestype 1 diabetes mellitus (t1dm)

Identifiers

PMID35165581
PMCPMC8830387
OpenAlexW4225326976

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.