Evidence map›Paper›PMID 35165440›Full record

ArticleNature2022

A gut-derived metabolite alters brain activity and anxiety behaviour in mice.

Brittany D Needham, Masanori Funabashi, Mark D Adame, Zhuo Wang, Joseph C Boktor, Jillian Haney, Wei-Li Wu, Claire Rabut, Mark S Ladinsky, Son-Jong Hwang and 10 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 252 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
252citing papers in PubMed, 2 pooled it
38.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

252 citing papers in PubMed, 2 syntheses or guidelines pooled it, 451 citations in OpenAlex.

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192 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 4 countries.

Brittany D NeedhamDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. bneedham@caltech.edu.ORCID http://orcid.org/0000-0002-0280-1886
Masanori FunabashiDepartment of Bioengineering and ChEM-H, Stanford University, Stanford, CA, USA.
Mark D AdameDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Zhuo WangDepartment of Psychiatry and the Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Joseph C BoktorDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Jillian HaneyDepartment of Neurology, University of California Los Angeles, Los Angeles, CA, USA.
Wei-Li WuDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Claire RabutDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.
Mark S LadinskyDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0002-1036-3513
Son-Jong HwangDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0002-3210-466X
Yumei GuoDepartment of Psychiatry and the Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Qiyun ZhuDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Jessica A GriffithsDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Rob KnightDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-0975-9019
Pamela J BjorkmanDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0002-2277-3990
Mikhail G ShapiroDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0002-0291-4215
Daniel H GeschwindDepartment of Neurology, University of California Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-2896-3450
Daniel P HolschneiderDepartment of Psychiatry and the Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Michael A FischbachDepartment of Bioengineering and ChEM-H, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-3079-8247
Sarkis K MazmanianDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. sarkis@caltech.edu.ORCID http://orcid.org/0000-0003-2713-1513
California Institute of Technology · USUniversity of Southern California · USUniversity of California, Los Angeles · USUniversity of California San Diego · USDaiichi Sankyo (Germany) · DEStanford University · US

Funding

Project 4 - Mechanistic studies on the role of the gut microbiome in models for Alzheimer's diseaseU19AG063744 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Rima F Kaddurah-Daouk · 2019 to 2026
$54.1M
X-ray Cryst. CoreP50GM082545 · NIGMS · UNIVERSITY OF UTAH · PI SUNDQUIST, WESLEY I. · 2007 to 2018
$51.1M
Project 3: Microbiota generated aryl sulfates and secondary bile acids in cardiometabolic diseaseP01HL147823 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI Zeneng Wang · 2019 to 2026
$17.0M
A complete map of the top 100 molecules from the gut microbiomeDP1DK113598 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FISCHBACH, MICHAEL ANDREW · 2016 to 2020
$5.5M
Investigating the Gut Microbiome for Novel Therapies and Diagnostics for AutismR01MH100556 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI MAZMANIAN, SARKIS K · 2013 to 2017
$2.8M
NHLBI NIH HHS P01 HL147823NIA NIH HHS U19 AG063744NIGMS NIH HHS P50 GM082545NIMH NIH HHS R01 MH100556
6 · The paper itself

Abstract

Integration of sensory and molecular inputs from the environment shapes animal behaviour. A major site of exposure to environmental molecules is the gastrointestinal tract, in which dietary components are chemically transformed by the microbiota

Indexed as

AnxietyGastrointestinal MicrobiomeMicrobiotaAnimalsBacteriaBrainMiceMice, Inbred C57BLMyelin SheathPhenols4-ethylphenolPhenols

Identifiers

PMID35165440
PMCPMC9170029
OpenAlexW4213093937

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.