Evidence map›Paper›PMID 35165416›Full record

ArticleNature cell biology2022

Metabolic determination of cell fate through selective inheritance of mitochondria.

Julia Döhla, Emilia Kuuluvainen, Nadja Gebert, Ana Amaral, Johanna I Englund, Swetha Gopalakrishnan, Svetlana Konovalova, Anni I Nieminen, Ella S Salminen, Rubén Torregrosa Muñumer and 9 more

Open access · greenAbstract read
In one paragraph

Article in Nature cell biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.

  1. Pooled it
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  18. Mitochondria - the CEO of the cell.Journal of cell science · 2025
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 3 countries.

Julia DöhlaInstitute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.
Emilia KuuluvainenInstitute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.
Nadja GebertLeibniz Institute on Aging-Fritz Lipmann Institute (FLI), Jena, Germany.
Ana AmaralDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Johanna I EnglundInstitute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0001-9637-6843
Swetha GopalakrishnanInstitute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.
Svetlana KonovalovaStem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Anni I NieminenInstitute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.
Ella S SalminenInstitute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.
Rubén Torregrosa MuñumerStem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Kati AhlqvistInstitute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.
Yang YangStem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Hien BuiInstitute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.
Timo OtonkoskiStem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0001-9190-2496
Reijo KäkeläFaculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.
Ville HietakangasInstitute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-9900-7549
Henna TyynismaaStem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Alessandro OriLeibniz Institute on Aging-Fritz Lipmann Institute (FLI), Jena, Germany.ORCID http://orcid.org/0000-0002-3046-0871
Pekka KatajistoInstitute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland. pekka.katajisto@helsinki.fi.ORCID http://orcid.org/0000-0002-3033-4189
University of Helsinki · FILeibniz Institute on Aging - Fritz Lipmann Institute (FLI) · DEKarolinska Institutet · SE

Funding

European Research Council 677809
6 · The paper itself

Abstract

Metabolic characteristics of adult stem cells are distinct from their differentiated progeny, and cellular metabolism is emerging as a potential driver of cell fate conversions

Indexed as

Cell DifferentiationCell LineageEnergy MetabolismGenes, MitochondrialAdult Stem CellsAnimalsCell LineCell ProliferationCellular SenescenceDNA, MitochondrialFemaleHumansMammary Glands, HumanMetabolomeMiceMice, Inbred C57BLDNA, MitochondrialProteome

Identifiers

PMID35165416
PMCPMC7612378
OpenAlexW4213254649

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.