ArticleCommunications biology2022
Visual learning in a virtual reality environment upregulates immediate early gene expression in the mushroom bodies of honey bees.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- When a bigger brain is better: The case of bee olfactory learning.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Divergent sensory transcriptomic profiles in positive and negative learning in Bicyclus Anynana butterflies.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Article
- Testing Bottom-up Cuing Effects on Target Detection and Discrimination in Bumblebees.Journal of insect behavior · 2026Article
- Assessing spinosad effect on honey bee olfactory conditioning using a microcontroller-based device.Frontiers in insect science · 2026Article
- Single-nucleus and spatial transcriptomics identify brain landscape of gene regulatory networks associated with behavioral maturation in honeybees.Nature communications · 2025Article
- Article
- Diversity of visual inputs to Kenyon cells of the Drosophila mushroom body.Nature communications · 2024Article
- Insights from the past: the work of Hans von Alten on the evolution of brain structure, ecological adaptation, and cognition in hymenopteran species.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- Movement during the acquisition of a visual landmark may be necessary for rapid learning in ants.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Article
- Reinforcement learning as a robotics-inspired framework for insect navigation: from spatial representations to neural implementation.Frontiers in computational neuroscience · 2024Article
- Physiological specialization of the brain in bumble bee castes: Roles of dopamine in mating-related behaviors in female bumble bees.PloS one · 2024Article
- Digital Phenotyping: A Game Changer for the Broiler Industry.Animals : an open access journal from MDPI · 2023Review
- Visual learning in tethered bees modifies flight orientation and is impaired by epinastine.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2023Article
- In search of behavioral and brain processes involved in honey bee dance communication.Frontiers in behavioral neuroscience · 2023Review
- Extended reality for biomedicine.Nature reviews. Methods primers · 2023Article
- The Neural Signature of Visual Learning Under Restrictive Virtual-Reality Conditions.Frontiers in behavioral neuroscience · 2022Article
- Editorial: The molecular mechanisms of experience-dependent plasticity in invertebrates.Frontiers in behavioral neuroscience · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 3 countries.
Funding
Abstract
Free-flying bees learn efficiently to solve numerous visual tasks. Yet, the neural underpinnings of this capacity remain unexplored. We used a 3D virtual reality (VR) environment to study visual learning and determine if it leads to changes in immediate early gene (IEG) expression in specific areas of the bee brain. We focused on kakusei, Hr38 and Egr1, three IEGs that have been related to bee foraging and orientation, and compared their relative expression in the calyces of the mushroom bodies, the optic lobes and the rest of the brain after color discrimination learning. Bees learned to discriminate virtual stimuli displaying different colors and retained the information learned. Successful learners exhibited Egr1 upregulation only in the calyces of the mushroom bodies, thus uncovering a privileged involvement of these brain regions in associative color learning and the usefulness of Egr1 as a marker of neural activity induced by this phenomenon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.