ArticleNature communications2022
Synthetic virions reveal fatty acid-coupled adaptive immunogenicity of SARS-CoV-2 spike glycoprotein.
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Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
3.2field-weighted citation impact, top 6% of its field
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Who cites it
25 citing papers in PubMed, 34 citations in OpenAlex.
- Sphingosine kinase-2 inhibition promotes immunogenic differentiation of myeloid-derived suppressor cells through an Acetyl-CoA carboxylase-phosphatidylcholine axis.Nature communications · 2026Article
- AI-guided prefusion stabilization of the human coronavirus OC43 spike protein enables universal embecovirus antigen design.PLoS pathogens · 2026Article
- Molecular insights into species-specific ACE2 recognition of coronavirus HKU5.Nature communications · 2025Article
- Alpha Linolenic and Stearic Acids Modulate Genes Related to Viral Entry and Inflammatory Response in THP-1 Derived Macrophages Exposed to SARS-CoV-2.Food science & nutrition · 2025Article
- In Silico Discovery of a Novel Antiviral Scaffold for SARS-CoV‑2 Targeting the Spike Glycoprotein through the Fatty Acid Binding Pocket.ACS omega · 2025Article
- A Reflection on the Use of Molecular Simulation to Respond to SARS-CoV-2 Pandemic Threats.The journal of physical chemistry letters · 2025Review
- Variant-Specific Interactions at the Plasma Membrane: Heparan Sulfate's Impact on SARS-CoV-2 Binding Kinetics.Analytical chemistry · 2025Article
- Disrupting SARS-CoV-2 Spike Protein Activity: A Virtual Screening and Binding Assay Study.International journal of molecular sciences · 2024Article
- Bottom-up synthetic immunology.Nature nanotechnology · 2024Review
- Vitamin K2 Supplementation in Hospitalised COVID-19 Patients: A Randomised Controlled Trial.Journal of clinical medicine · 2024Article
- An Efficient Method for the Production of High-Purity Bioinspired Large Unilamellar Vesicles.ACS synthetic biology · 2024Article
- Bottom-up Assembled Synthetic SARS-CoV-2 Miniviruses Reveal Lipid Membrane Affinity of Omicron Variant Spike Glycoprotein.ACS nano · 2023Article
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- Accelerating drug target inhibitor discovery with a deep generative foundation model.Science advances · 2023Article
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- Further quantitative in silico analysis of SARS-CoV-2 S-RBD Omicron BA.4, BA.5, BA.2.75, BQ.1, and BQ.1.1 transmissibility.Talanta · 2023Article
- In Silico Discovery of Small Molecule Modulators Targeting the Achilles' Heel of SARS-CoV-2 Spike Protein.ACS central science · 2023Article
- Identifying SARS-CoV-2 Drugs Binding to the Spike Fatty Acid Binding Pocket Using In Silico Docking and Molecular Dynamics.International journal of molecular sciences · 2023Article
- SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly.The Journal of experimental medicine · 2023Article
- Cryo-EM reveals binding of linoleic acid to SARS-CoV-2 spike glycoprotein, suggesting an antiviral treatment strategy.Acta crystallographica. Section D, Structural biology · 2023Article
Corrections and comments
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Authors and funding
17 authors at 6 institutions in 2 countries.
Oskar StauferDepartment for Cellular Biophysics, Max Planck Institute for Medical Research, Jahnstraße 29, 69120, Heidelberg, Germany. oskar.staufer@mr.mpg.de.ORCID http://orcid.org/0000-0002-8015-3132
Kapil GuptaSchool of Biochemistry, Biomedical Sciences, University of Bristol, 1 Tankard's Close, Bristol, BS8 1TD, UK.ORCID http://orcid.org/0000-0002-2115-3503
Jochen Estebano Hernandez BücherDepartment for Cellular Biophysics, Max Planck Institute for Medical Research, Jahnstraße 29, 69120, Heidelberg, Germany.
Fabian KohlerDepartment of Physics, Technical University of Munich, 85748, Garching, Germany.
Christian SiglDepartment of Physics, Technical University of Munich, 85748, Garching, Germany.
Gunjita SinghSchool of Biochemistry, Biomedical Sciences, University of Bristol, 1 Tankard's Close, Bristol, BS8 1TD, UK.
Kate VasileiouSchool of Biochemistry, Biomedical Sciences, University of Bristol, 1 Tankard's Close, Bristol, BS8 1TD, UK.
Ana Yagüe RelimpioDepartment for Cellular Biophysics, Max Planck Institute for Medical Research, Jahnstraße 29, 69120, Heidelberg, Germany.
Meline MacherDepartment for Cellular Biophysics, Max Planck Institute for Medical Research, Jahnstraße 29, 69120, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-9184-4959
Sebastian FabritzDepartment for Chemical Biology, Max Planck Institute for Medical Research, Jahnstraße 29, 69120, Heidelberg, Germany.
Hendrik DietzMax Planck School Matter to Life, Jahnstraße 29, 69120, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-1270-3662
Elisabetta Ada Cavalcanti AdamDepartment for Cellular Biophysics, Max Planck Institute for Medical Research, Jahnstraße 29, 69120, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-0243-1552
Christiane SchaffitzelSchool of Biochemistry, Biomedical Sciences, University of Bristol, 1 Tankard's Close, Bristol, BS8 1TD, UK.ORCID http://orcid.org/0000-0002-1516-9760
Alessia RuggieriDepartment of Infectious Diseases, Molecular Virology, Center for Integrated Infectious Disease Research, University of Heidelberg, Im Neuenheimer Feld 344, 69120, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-9981-3308
Ilia PlatzmanDepartment for Cellular Biophysics, Max Planck Institute for Medical Research, Jahnstraße 29, 69120, Heidelberg, Germany.
Imre BergerMax Planck-Bristol Center for Minimal Biology, University of Bristol, 1 Tankard's Close, Bristol, BS8 1TD, UK. imre.berger@bristol.ac.uk.ORCID http://orcid.org/0000-0001-7518-9045
Joachim P SpatzDepartment for Cellular Biophysics, Max Planck Institute for Medical Research, Jahnstraße 29, 69120, Heidelberg, Germany. spatz@mr.mpg.de.ORCID http://orcid.org/0000-0003-3419-9807
Heidelberg University · DEUniversity of Bristol · GBMax Planck Institute for Medical Research · DEPhilips (United Kingdom) · GBTechnical University of Munich · DEMax Planck School Matter to Life
Funding
Biotechnology and Biological Sciences Research Council BB/L01386X/1Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research) MaxSynBio ConsortiumDeutsche Forschungsgemeinschaft (German Research Foundation) Gottfried-Wilhelm-Leibniz ProgramDeutsche Forschungsgemeinschaft (German Research Foundation) SFB 1129Max-Planck-Gesellschaft (Max Planck Society) Max Planck School Matter to LifeWellcome Trust
Abstract
SARS-CoV-2 infection is a major global public health concern with incompletely understood pathogenesis. The SARS-CoV-2 spike (S) glycoprotein comprises a highly conserved free fatty acid binding pocket (FABP) with unknown function and evolutionary selection advantage
Indexed as
A549 CellsAllosteric SiteAmino Acid SequenceAntibodies, NeutralizingAntibodies, ViralBinding SitesCells, CulturedCOVID-19Cryoelectron MicroscopyElectron Microscope TomographyFatty Acid-Binding ProteinsFatty AcidsHumansMCF-7 CellsMicroscopy, ConfocalProtein BindingAntibodies, NeutralizingAntibodies, ViralFatty Acid-Binding ProteinsFatty AcidsSpike Glycoprotein, Coronavirusspike glycoprotein, SARS-CoV
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.