ArticleNature communications2022
Rhodium hydride enabled enantioselective intermolecular C-H silylation to access acyclic stereogenic Si-H.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Synthesis of functionalized hydrosilanes via titanium-catalyzed hydroboration and hydrogenation of C(spNature communications · 2026Article
- Photo-induced ring-maintaining hydrosilylation of unactivated alkenes with hydrosilacyclobutanes.Nature communications · 2025Article
- Enantioselective construction of silicon-stereogenic vinylsilanes from simple alkenes.Nature communications · 2025Article
- Carbon-silicon-switch effect in enantioselective construction of silicon-stereogenic center from silacyclohexadienones.Nature communications · 2024Article
- Intermolecular C-H silylations of arenes and heteroarenes with mono-, bis-, and tris(trimethylsiloxy)hydrosilanes: control of silane redistribution under operationally diverse approaches.Chemical science · 2024Article
- Stereospecific synthesis of silicon-stereogenic optically active silylboranes and general synthesis of chiral silyl Anions.Nature communications · 2023Article
- Enantioconvergent construction of stereogenic silicon via Lewis base-catalyzed dynamic kinetic silyletherification of racemic chlorosilanes.Nature communications · 2023Article
- A direct method to access various functional arylalkoxysilanes by Rh-catalysed intermolecular C-H silylation of alkoxysilanes.Chemical science · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
The tremendous success of stereogenic carbon compounds has never ceased to inspire researchers to explore the potentials of stereogenic silicon compounds. Intermolecular C-H silylation thus represents the most versatile and straightforward strategy to construct C-Si bonds, however, its enantioselective variant has been scarcely reported to date. Herein we report a protocol that allows for the enantioselective intermolecular C-H bond silylation, leading to the construction of a wide array of acyclic stereogenic Si-H compounds under simple and mild reaction conditions. Key to the success is (1) a substrate design that prevents the self-reaction of prochiral silane and (2) the employment of a more reactive rhodium hydride ([Rh]-H) catalyst as opposed to the commonly used rhodium chloride ([Rh]-Cl) catalyst. This work unveils opportunities in converting simple arenes into value-added stereogenic silicon compounds.
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Registered trials
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