Evidence map›Paper›PMID 35165267›Full record

ArticleNature communications2022

Genetic associations with carotid intima-media thickness link to atherosclerosis with sex-specific effects in sub-Saharan Africans.

Palwende Romuald Boua, Jean-Tristan Brandenburg, Ananyo Choudhury, Hermann Sorgho, Engelbert A Nonterah, Godfred Agongo, Gershim Asiki, Lisa Micklesfield, Solomon Choma, Francesc Xavier Gómez-Olivé and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 6 countries.

Palwende Romuald BouaClinical Research Unit of Nanoro, Institut de Recherche en Sciences de la Santé, Centre national de la Recherche scientifique et technologique (CNRST), Nanoro, Burkina Faso. romyboua@gmail.com.ORCID http://orcid.org/0000-0001-8325-2665
Jean-Tristan BrandenburgSydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID http://orcid.org/0000-0003-0197-2648
Ananyo ChoudhurySydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID http://orcid.org/0000-0001-8225-9531
Hermann SorghoClinical Research Unit of Nanoro, Institut de Recherche en Sciences de la Santé, Centre national de la Recherche scientifique et technologique (CNRST), Nanoro, Burkina Faso.
Engelbert A NonterahNavrongo Health Research Centre, Ghana Health Service, Navrongo, Ghana.ORCID http://orcid.org/0000-0001-8491-6478
Godfred AgongoNavrongo Health Research Centre, Ghana Health Service, Navrongo, Ghana.
Gershim AsikiAfrican Population and Health Research Center, Nairobi, Kenya.ORCID http://orcid.org/0000-0002-9966-1153
Lisa MicklesfieldMRC/Wits Developmental Pathways for Health Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID http://orcid.org/0000-0002-4994-0779
Solomon ChomaDepartment of Pathology and Medical Sciences, University of Limpopo, Polokwane, South Africa.
Francesc Xavier Gómez-OlivéMRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID http://orcid.org/0000-0002-4876-0848
Scott HazelhurstSchool of Electrical and Information Engineering, University of the Witwatersrand, Johannesburg, South Africa.ORCID http://orcid.org/0000-0002-0581-149X
Halidou TintoClinical Research Unit of Nanoro, Institut de Recherche en Sciences de la Santé, Centre national de la Recherche scientifique et technologique (CNRST), Nanoro, Burkina Faso.
Nigel J CrowtherDepartment of Chemical Pathology, National Health Laboratory Service, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Christopher G MathewSydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID http://orcid.org/0000-0003-4178-1838
Michèle RamsaySydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. michele.ramsay@wits.ac.za.ORCID http://orcid.org/0000-0002-4156-4801
AWI-Gen Study
H3Africa Consortium
University of the Witwatersrand · ZANational Health Laboratory Service · ZACentre National de la Recherche Scientifique et Technologique · BFAfrican Population and Health Research Center · KENavrongo Health Research Centre · GHUniversity of Limpopo · ZAUtrecht University · NL

Funding

Shared Core: Biobanking, Bioinformatics and Data ManagementU54HG006938 · NHGRI · WITS HEALTH CONSORTIUM (PTY), LTD · PI RAMSAY, MICHELE MICHELE · 2012 to 2022
$12.2M
Wits Non-communicable Disease Research Leadership ProgramD43TW008330 · FIC · WITS HEALTH CONSORTIUM (PTY), LTD · PI CROWTHER, NIGEL JOHN, KLIPSTEIN-GROBUSCH, KERSTIN · 2010 to 2014
$985k
FIC NIH HHS D43 TW008330NHGRI NIH HHS U54 HG006938
6 · The paper itself

Abstract

Atherosclerosis precedes the onset of clinical manifestations of cardiovascular diseases (CVDs). We used carotid intima-media thickness (cIMT) to investigate genetic susceptibility to atherosclerosis in 7894 unrelated adults (3963 women, 3931 men; 40 to 60 years) resident in four sub-Saharan African countries. cIMT was measured by ultrasound and genotyping was performed on the H3Africa SNP Array. Two new African-specific genome-wide significant loci for mean-max cIMT, SIRPA (p = 4.7E-08), and FBXL17 (p = 2.5E-08), were identified. Sex-stratified analysis revealed associations with one male-specific locus, SNX29 (p = 6.3E-09), and two female-specific loci, LARP6 (p = 2.4E-09) and PROK1 (p = 1.0E-08). We replicate previous cIMT associations with different lead SNPs in linkage disequilibrium with SNPs primarily identified in European populations. Our study find significant enrichment for genes involved in oestrogen response from female-specific signals. The genes identified show biological relevance to atherosclerosis and/or CVDs, sex-differences and transferability of signals from non-African studies.

Indexed as

AdultAfrica South of the SaharaAtherosclerosisAutoantigensCardiovascular DiseasesCarotid Intima-Media ThicknessFemaleGastrointestinal HormonesGenetic Predisposition to DiseaseGenomeHistonesHumansMaleMiddle AgedPolymorphism, Single NucleotideRibonucleoproteinsAutoantigensGastrointestinal HormonesHistonesPROK1 protein, humanRibonucleoproteinsSorting NexinsSS-B AntigenVascular Endothelial Growth Factor, Endocrine-Gland-Derived

Identifiers

PMID35165267
PMCPMC8844072
OpenAlexW4213252202

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.